Loading...
Please wait, while we are loading the content...
Double-hit lymphoma with a feature of follicular lymphoma concurrent with clonally related B lymphoblastic leukemia : a preference of transformation for the bone marrow.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kishimoto, Wataru Shirase, Tomoyuki Chihara, Dai Takuya Arimoto-Miyamoto, Kazue Takeoka, Tomoharu Tsuji, Masaaki Ohno, Tatsuharu Kita, Kenkichi |
| Copyright Year | 2012 |
| Abstract | We describe a 65-year-old woman with follicular lymphoma (FL), grade 1, stage IV, which occurred concurrently with B lymphoblastic leukemia/lymphoma. Through the evaluation of FL, the cells that were morphologically suspected of having undergone transformation were found in the bone marrow, and flow cytometric and cytogenetic analyses detected the transformed population that suggested concomitant t(8;22) with typical t(14;18) FL cells. Repeated analyses of the lymph nodes demonstrated the typical morphological, phenotypic, and cytogenetic features of FL. The patient received several multiagent chemotherapy regimens, but the disease gradually became resistant, and the patient died of leukemic progression. In B-cell malignancies, cases involving both BCL2 and MYC translocations simultaneously, so-called "double-hit leukemia/lymphoma (DHL)", have occasionally been reported. Patients with this type of translocation have a very poor clinical outcome, and no standard therapy has been established. In our case, FL was supposed to have transformed into B lymphoblastic leukemia via Burkitt's lymphoma-like phase. Our case is unique in that the transformed DHL cells, derived from clonally related FL cells, showed ongoing transformation from Burkitt-like feature to B lymphoblastic leukemia exclusively in the bone marrow, which suggests that the bone marrow may provide a preferable milieu for malignant transformation. Similar cases should be accumulated and analyzed carefully. |
| Starting Page | 1468 |
| Ending Page | 1478 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jsltr.org/journal/52-2/5202_05.pdf |
| PubMed reference number | 23037627v1 |
| Volume Number | 52 |
| Issue Number | 2 |
| Journal | Journal of clinical and experimental hematopathology : JCEH |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bone Marrow Chemotherapy-Induced Febrile Neutropenia Chromosomal translocation Cytogenetic Analysis Double-Hit Lymphoma Leukemia, B-Cell Lymphoma, Follicular Lymphoma, Large-Cell, Follicular Lymphoma, Non-Hodgkin Patients leukemia lymph nodes lymphoblast stage IV childhood Hodgkin's lymphoma t(14;18) |
| Content Type | Text |
| Resource Type | Article |
