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Liver blood dynamics after bariatric surgery: the effects of mixed-meal test and incretin infusions
| Content Provider | Semantic Scholar |
|---|---|
| Author | Honka, Henri Koffert, Jukka P. Kauhanen, S. Petteri Kudomi, Nobuyuki Hurme, Saija Mari, Andrea Lindqvist, Andreas Lövgren Wierup, Nils Parkkola, Riitta Groop, Leif Nuutila, Pirjo |
| Copyright Year | 2018 |
| Abstract | AIMS/HYPOTHESIS The mechanisms for improved glycemic control after bariatric surgery in subjects with type 2 diabetes (T2D) are not fully known. We hypothesized that dynamic hepatic blood responses to a mixed-meal are changed after bariatric surgery in parallel with an improvement in glucose tolerance. METHODS A total of ten morbidly obese subjects with T2D were recruited to receive a mixed-meal and a glucose-dependent insulinotropic polypeptide (GIP) infusion before and early after (within a median of less than three months) bariatric surgery, and hepatic blood flow and volume (HBV) were measured repeatedly with combined positron emission tomography/MRI. Ten lean non-diabetic individuals served as controls. RESULTS Bariatric surgery leads to a significant decrease in weight, accompanied with an improved β-cell function and glucagon-like peptide 1 (GLP-1) secretion, and a reduction in liver volume. Blood flow in portal vein (PV) was increased by 1.65-fold (P = 0.026) in response to a mixed-meal in subjects after surgery, while HBV decreased in all groups (P < 0.001). When the effect of GIP infusion was tested separately, no change in hepatic arterial and PV flow was observed, but HBV decreased as seen during the mixed-meal test. CONCLUSIONS/INTERPRETATION Early after bariatric surgery, PV flow response to a mixed-meal is augmented, improving digestion and nutrient absorption. GIP influences the post-prandial reduction in HBV thereby diverting blood to the extrahepatic sites. |
| Starting Page | 888 |
| Ending Page | 896 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://ec.bioscientifica.com/downloadpdf/journals/ec/7/7/EC-18-0234.pdf |
| PubMed reference number | 29941634v1 |
| Alternate Webpage(s) | https://doi.org/10.1530/EC-18-0234 |
| DOI | 10.1530/ec-18-0234 |
| Journal | Endocrine connections |
| Volume Number | 7 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bariatric Surgery Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent GCG gene GIP gene Glucagon-Like Peptide Receptors Glucagon-Like Peptides Hepatitis B Incretins Obesity Polycythemia Vera Polypeptides Portal vein structure Positron-Emission Tomography Positrons Protein Digestion (research activity) Thoracic Surgery, Video-Assisted glucose tolerance |
| Content Type | Text |
| Resource Type | Article |
