NDLI: Chronic l-Dopa fails to lessen rebound enhancement of self-stimulation after chronic haloperidol

Content Provider	Semantic Scholar
Author	Rose, I. R. Celine Mintz, Matti Herberg, Lieselotte
Copyright Year	1988
Abstract	Chronic treatment with haloperidol (approximately 4.8 mg/rat/day PO for 18 days) severely impaired variable-interval hypothalamic self-stimulation. Cessation of treatment was followed by a strong rebound increase in response rates at submaximal currents, to well above pretreatment rates. The rebound increase in responding was not prevented (and at submaximal currents was actually enhanced) by treatment with l-dopa plus benserazide (respectively 240 and 60 mg/kg/day PO) for 6 days after withdrawal of haloperidol. This result is at variance with previously reported findings.
Starting Page	585
Ending Page	588
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0091-3057(88)90069-X
PubMed reference number	3211967
Journal	Medline
Volume Number	30
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/009130578890069X
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/009130578890069X?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0091-3057%2888%2990069-X
Journal	Pharmacology Biochemistry and Behavior
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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Chronic l-Dopa fails to lessen rebound enhancement of self-stimulation after chronic haloperidol