NDLI: Increase in mesolimbic electrical self-stimulation after chronic haloperidol: reversal by L-DOPA or lithium

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Increase in mesolimbic electrical self-stimulation after chronic haloperidol: reversal by L-DOPA or lithium

Content Provider	Semantic Scholar
Author	Seeger, Thomas Francis Gardner, Eliot L. Bridger, Wagner F.
Copyright Year	1981
Abstract	After chronic neuroleptic drug treatment, an increase in electrical intracranial self-stimulation (ICSS) rate is seen from electrodes in the A10 dopaminergic nucleus. This increase, which persists for approximately 3 weeks following drug withdrawal, is believed to represent a behavioral manifestation of drug-induced dopaminergic synaptic supersensitivity. Chronic L-DOPA caused a partial reversal of haloperidol-induced ICSS increase. Lithium carbonate, given concurrently with the haloperidol, partially prevented the development of ICSS supersensitivity. It is concluded that dopaminergic synaptic sensitivity has a two-way modulatory capability.
Starting Page	404
Ending Page	409
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1016/0006-8993(81)90525-4
PubMed reference number	6790126
Journal	Medline
Volume Number	215
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0006899381905254
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0006899381905254?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0006-8993%2881%2990525-4
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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