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Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Carmo, Ricardo Oliveira, Guilherme C. Guimarães, Mark Drew Crosland Oliveira, Marina Da Silva Lima, Angela Aparecida Buzek, S. C. Corrêa-Oliveira, Rodrigo Rocha, Manoel Otávio Das Costa |
| Copyright Year | 2002 |
| Abstract | We determined and analyzed risk factors of hepatitis C virus (HCV)-infected Brazilian hemophiliacs according to their virological, clinical and epidemiological characteristics. A cross-sectional and retrospective study of 469 hemophiliacs was carried out at a Brazilian blood center starting in October 1997. The prevalence of HCV infection, HCV genotypes and factors associated with HCV RNA detection was determined. The seroprevalence of anti-HCV antibodies (ELISA-3.0) was 44.6% (209/469). Virological, clinical and epidemiological assessments were completed for 162 positive patients. There were seven (4.3%) anti-HCV seroconversions between October 1992 and October 1997. During the same period, 40.8% of the positive anti-HCV hemophiliacs had abnormal alanine transaminase (ALT) levels. Plasma HCV RNA was detected by nested-RT-PCR in 116 patients (71.6%). RFLP analysis showed the following genotype distribution: HCV-1 in 98 hemophiliacs (84.5%), HCV-3 in ten (8.6%), HCV-4 in three (2.6%), HCV-2 in one (0.9%), and not typeable in four cases (3.4%). Univariate analysis indicated that older age (P = 0.017) and abnormal ALT levels (P = 0.010) were associated with HCV viremia, while the presence of inhibitor antibodies (P = 0.024) and HBsAg (P = 0.007) represented a protective factor against the presence of HCV RNA. These findings may contribute to a better understanding of the relationship between HCV infection and hemophilia. |
| Starting Page | 471 |
| Ending Page | 474 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.scielo.br/pdf/bjmbr/v35n5/4358.pdf |
| PubMed reference number | 12011945v1 |
| Volume Number | 35 |
| Issue Number | 5 |
| Journal | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alanine Transaminase Epidemiology Evaluation procedure Genotype HCV viral load Hemophilia, NOS Hepatitis B Surface Antigens Hepatitis C Antibodies Hepatitis C Virus Infection Patients Protective Factors RNA Restriction fragment length polymorphism Reverse Transcriptase Polymerase Chain Reaction Seroconversion Transaminases Viremia hemophiliacs |
| Content Type | Text |
| Resource Type | Article |
