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Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study
| Content Provider | Scilit |
|---|---|
| Author | Carmo, R. A. Oliveira, G. C. Guimarães, M. D. C. Oliveira, M. S. Lima, A. A. Buzek, S. C. Corrêa-Oliveira, R. Rocha, M. O. C. |
| Copyright Year | 2002 |
| Description | We determined and analyzed risk factors of hepatitis C virus (HCV)-infected Brazilian hemophiliacs according to their virological, clinical and epidemiological characteristics. A cross-sectional and retrospective study of 469 hemophiliacs was carried out at a Brazilian blood center starting in October 1997. The prevalence of HCV infection, HCV genotypes and factors associated with HCV RNA detection was determined. The seroprevalence of anti-HCV antibodies (ELISA-3.0) was 44.6% (209/469). Virological, clinical and epidemiological assessments were completed for 162 positive patients. There were seven (4.3%) anti-HCV seroconversions between October 1992 and October 1997. During the same period, 40.8% of the positive anti-HCV hemophiliacs had abnormal alanine transaminase (ALT) levels. Plasma HCV RNA was detected by nested-RT-PCR in 116 patients (71.6%). RFLP analysis showed the following genotype distribution: HCV-1 in 98 hemophiliacs (84.5%), HCV-3 in ten (8.6%), HCV-4 in three (2.6%), HCV-2 in one (0.9%), and not typeable in four cases (3.4%). Univariate analysis indicated that older age (P = 0.017) and abnormal ALT levels (P = 0.010) were associated with HCV viremia, while the presence of inhibitor antibodies (P = 0.024) and HBsAg (P = 0.007) represented a protective factor against the presence of HCV RNA. These findings may contribute to a better understanding of the relationship between HCV infection and hemophilia. |
| Related Links | http://www.scielo.br/pdf/bjmbr/v35n5/4358.pdf http://www.scielo.br/scielo.php?script=sci_pdf&pid=S0100-879X2002000500012&lng=en&nrm=iso&tlng=en |
| Ending Page | 598 |
| Page Count | 10 |
| Starting Page | 589 |
| ISSN | 0100879X |
| e-ISSN | 1414431X |
| DOI | 10.1590/s0100-879x2002000500012 |
| Journal | Brazilian Journal of Medical and Biological Research |
| Issue Number | 5 |
| Volume Number | 35 |
| Language | English |
| Publisher | FapUNIFESP (SciELO) |
| Publisher Date | 2002-05-01 |
| Access Restriction | Open |
| Subject Keyword | Brazilian Journal of Medical and Biological Research Hepatitis C Virus Hcv Genotypes Chronic Liver Disease |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Cell Biology Physiology Medicine Biochemistry Biophysics Immunology Pharmacology, Toxicology and Pharmaceutics |
