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Low blood flow at onset of moderate-intensity exercise does not limit muscle oxygen uptake.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nyberg, Michael Mortensen, Stefan Peter Saltin, Bengt Hellsten, Ylva Bangsbo, Jens |
| Copyright Year | 2010 |
| Abstract | The effect of low blood flow at onset of moderate-intensity exercise on the rate of rise in muscle oxygen uptake was examined. Seven male subjects performed a 3.5-min one-legged knee-extensor exercise bout (24 +/- 1 W, mean +/- SD) without (Con) and with (double blockade; DB) arterial infusion of inhibitors of nitric oxide synthase (N(G)-monomethyl-l-arginine) and cyclooxygenase (indomethacin) to inhibit the synthesis of nitric oxide and prostanoids, respectively. Leg blood flow and leg oxygen delivery throughout exercise was 25-50% lower (P < 0.05) in DB compared with Con. Leg oxygen extraction (arteriovenous O(2) difference) was higher (P < 0.05) in DB than in Con (5 s: 127 +/- 3 vs. 56 +/- 4 ml/l), and leg oxygen uptake was not different between Con and DB during exercise. The difference between leg oxygen delivery and leg oxygen uptake was smaller (P < 0.05) during exercise in DB than in Con (5 s: 59 +/- 12 vs. 262 +/- 39 ml/min). The present data demonstrate that muscle blood flow and oxygen delivery can be markedly reduced without affecting muscle oxygen uptake in the initial phase of moderate-intensity exercise, suggesting that blood flow does not limit muscle oxygen uptake at the onset of exercise. Additionally, prostanoids and/or nitric oxide appear to play important roles in elevating skeletal muscle blood flow in the initial phase of exercise. |
| Starting Page | 37 |
| Ending Page | 51 |
| Page Count | 15 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ajpregu.physiology.org/content/ajpregu/early/2010/01/20/ajpregu.00730.2009.full.pdf |
| Alternate Webpage(s) | http://ajpregu.physiology.org/content/ajpregu/298/3/R843.full.pdf |
| PubMed reference number | 20089709v1 |
| Alternate Webpage(s) | https://doi.org/10.1152/ajpregu.00730.2009 |
| DOI | 10.1152/ajpregu.00730.2009 |
| Journal | American journal of physiology. Regulatory, integrative and comparative physiology |
| Volume Number | 298 |
| Issue Number | 3 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Arginine Derangement of knee Fifty Nine Indomethacin Milliliter per Minute Muscle Nitric Oxide Synthase Oxygen 100 % Gas for Inhalation Physiological Sexual Disorders Prostaglandins Small |
| Content Type | Text |
| Resource Type | Article |
