NDLI: Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway.

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Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway.

Content Provider	Semantic Scholar
Author	Zhao, Xingwei Zhang, Qiang Chen, Liang An
Copyright Year	2016
Abstract	Research on triptolide, a diterpenoid epoxide found in the Thunder God Vine Tripterygium wilfordii, has increased our knowledge of the pharmacology, pharmacokinetics, toxicology and clinical application of this agent. In the present study, we aimed to identify the effects of triptolide on the apoptosis of osteosarcoma cells and to evaluate the anti-proliferative action of this agent. MG-63 cells were treated either with various doses of triptolide (50, 100 or 200 nM) or DMSO for 6, 12 and 24 h. Treatment with triptolide effectively suppressed the cell viability and induced the apoptosis of osteosarcoma MG-63 cells as detected by MTT assay and flow cytometry, respectively. In addition, by using caspase-3, caspase-8 and caspase-9 activity assays and western blot analysis, the anticancer effects of triptolide against osteosarcoma growth were found to involve activation of the DR-5/p53/Bax/caspase-9/ caspase-3 signaling pathway and the DR-5/FADD/caspase-8/lysosomal/cathepsin B/caspase-3 signaling pathway in the MG-63 cells. An important factor in the anticancer effects of triptolide against osteosarcoma was TRAIL-DR-5. The data suggest that triptolide may be a potential novel chemotherapeutic agent for osteosarcoma and acts through the TRAIL-DR-5 signaling pathway.
Starting Page	555
Ending Page	560
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.spandidos-publications.com/10.3892/or.2016.4957/download
PubMed reference number	27461934v1
Alternate Webpage(s)	https://doi.org/10.3892/or.2016.4957
DOI	10.3892/or.2016.4957
Journal	Oncology reports
Volume Number	36
Issue Number	3
Language	English
Access Restriction	Open
Subject Keyword	Antineoplastic Agents Apoptosis Cathepsins Cell Survival Diagnostic Service Section ID - Toxicology Dimethyl Sulfoxide Epoxy Compounds Flow Cytometry Osteosarcoma Pharmacology Signal Transduction Pathways Tripterygium caspase-3 caspase-8 caspase-9 diterpenoid biosynthetic process monooxyethylene trimethylolpropane tristearate triptolide
Content Type	Text
Resource Type	Article

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