NDLI: miR-27a-3p targeting RXRα promotes colorectal cancer progression by activating Wnt/β-catenin pathway

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miR-27a-3p targeting RXRα promotes colorectal cancer progression by activating Wnt/β-catenin pathway

Content Provider	Semantic Scholar
Author	Liang, Jiangtao Tang, Jianming Shi, Huijuan Zhen, Tiantian Duan, Jing Kang, Lili Zhang, Fenfen Dong, Yu Han, Anjia
Copyright Year	2017
Abstract	This study aimed to elucidate how miR-27a-3p modulates the Wnt/β-catenin signaling pathway to promote colorectal cancer (CRC) progression. Our results showed that the expression of miR-27a-3p was up-regulated in CRC and closely associated with histological differentiation, clinical stage, distant metastasis and CRC patients' survival. miR-27a-3p mimic suppressed apoptosis and promoted proliferation, migration, invasion of CRC cells in vitro and in vivo. Whereas miR-27a-3p inhibitor promoted apoptosis and suppressed proliferation, migration, invasion of CRC cells in vitro and in vivo. Furthermore, RXRα was the target gene of miR-27a-3p in CRC. miR-27a-3p expression negatively correlated with RXRα expression in CRC tissues. The underlining mechanism study showed that miR-27a-3p/RXRα/Wnt/β-catenin signaling pathway is involved in CRC progression. In conclusion, our findings first demonstrate that miR-27a-3p is a prognostic and/or potential therapeutic biomarker for CRC patients and RXRα as miR-27a-3p targeting gene plays an important role in activation of the Wnt/β-catenin pathway during CRC progression.
Starting Page	82991
Ending Page	83008
Page Count	18
File Format	PDF HTM / HTML
DOI	10.18632/oncotarget.19635
Alternate Webpage(s)	http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=19635&path%5B%5D=62727
PubMed reference number	28778091
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.19635
Journal	Medline
Volume Number	8
Journal	Oncotarget
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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