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Substance p (SP), neurokinin a (NKA), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in synovial fluid from knee joints in patients suffering from rheumatoid arthritis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Larsson, Jonas Ekblom, Anneli Henriksson, Kristina Lundeberg, Thomas Theodorsson, Elvar |
| Copyright Year | 1990 |
| Abstract | AIM OF INVESTIGATION: Recently the involvement of peptide containing somatic afferent nerve fibers as well as sympathetic efferents in the pathophysiology of joint inflammation has been discussed. A relationship has been found between peptldergic fibers and arthritis in animal models. The presence of the various peptides in normal and inflammed human joints is unknown. We have therefore studied the presence of some peptides, proposed to be of importance in arthritis, in inflammed and non-inflammed human knee joints. METHODS: 31 patients, aged 18-73 years, participated in the study: 18 patients suffered from rheumatoid arthritis (group A) and 13 of meniscal/cruciate ligament injuries without any signs of local inflammation (group Bl. 6/18 in group A and all in group B were subjected to arthroscopy (in epidural anaesthesia) and 12/18 in group A to arthrocentesis (without any local anaesthesia). Samples from synovial fluid were extracted on a reversephase Cl8 cartridge and analyzed using competitive radioimmunoassays with antiserum SP2 &PI, K12 (NKA), NPYl (NPY), R8 (CGRP) and (VIP). RESULTS: No SP was detected in any of the samples (detection limit 0.1 fmol/mll. Significantly less NKA was found in the arthritis patients (2.4k2.55 fmol/ml) versus the controls (6.4f2.34). The arthritis patients displayed a significantly higher concentration of CGRP (41f7.76) and NPY (9.2f5.76 ) vs the controls (CGRP 16f9.78 and NPY 4.3f4.46). VIP was only found sporadically. CONCLUSION: The results indicate an involvement of peptides from sensory afferents and sympathetic efferents in rheumatoid arthritis in humans. However, in contrast to animal experiments, no SP could be detected in either controls nor arthritis patients. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3959(90)92169-Q |
| Volume Number | 41 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/030439599092169Q |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/030439599092169Q?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3959%2890%2992169-Q |
| Journal | Pain |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
