NDLI: Concentration of Substance P, Neurokinin A, Calcitonin Gene-related Peptide, Neuropeptide Y and Vasoactive Intestinal Polypeptide in Synovial Fluid from Knee Joints in Patients Suffering from Rheumatoid Arthritis

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Concentration of Substance P, Neurokinin A, Calcitonin Gene-related Peptide, Neuropeptide Y and Vasoactive Intestinal Polypeptide in Synovial Fluid from Knee Joints in Patients Suffering from Rheumatoid Arthritis

Content Provider	Scilit
Author	Larsson, J. Ekblom, A. Henriksson, K. Lundeberg, T. Theodorsson, Elvar
Copyright Year	1991
Description	Journal: Scandinavian Journal of Rheumatology We have studied the presence of five neuropeptides in knee joint synovial fluid from either patients suffering from rheumatoid arthritis and pain (n=18) or being subjected to arthroscopy due to meniscal/cruciate ligament injuries (n=13). Radioimmunoassay technique was used for peptide analysis using antisera SP2 against substance P (SP), K12 against neurokinin A (NKA), CGRPR8 against calcitonin gene-related peptide (CGRP), NPY1 against neuropeptide Y (NPY) and VIP2 agains vasoactive intestinal polypeptide (VIP). No SP could be detected, and lower levels of NKA was found in arthritic joints vs controls. CGRP and NPY was found in higher concentrations in arthritic patients vs controls. VIP was found sporadically in both arhtritis and control patients. Our data show some quantitative differences between patients suffering rheumatoid arhtritis and pain, and patients with non-inflammed joints without pain; indicating an involvement of peptidergic fibers in arthritis in humans.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03009749109096808
Ending Page	335
Page Count	10
Starting Page	326
ISSN	03009742
e-ISSN	15027732
DOI	10.3109/03009749109096808
Journal	Scandinavian Journal of Rheumatology
Issue Number	5
Volume Number	20
Language	English
Publisher	Informa UK Limited
Publisher Date	1991-01-01
Access Restriction	Open
Subject Keyword	Journal: Scandinavian Journal of Rheumatology Concentrations Patients Suffering From Rheumatoid
Content Type	Text
Subject	Immunology and Allergy Immunology Rheumatology

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