Loading...
Please wait, while we are loading the content...
Similar Documents
Non-NMDA and NMDA receptors transmit area postrema input to aortic baroreceptor neurons in NTS.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chen, C. Y. Bonham, Ann C. |
| Copyright Year | 1998 |
| Abstract | We sought to determine whether glutamate acting at both N-methyl-D-aspartate (NMDA) and non-NMDA receptors transmits area postrema (AP) excitatory inputs to nucleus tractus solitarii (NTS) neurons in the aortic baroreceptor or vagal afferent pathways in vivo. In alpha-chloralose-anesthetized rabbits, we recorded extracellular NTS neuronal responses to low-frequency aortic depressor nerve (ADN), vagus nerve, and AP stimulation and to iontophoresis of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid and NMDA during control, iontophoresis of 2, 3-dihdroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX), DL-2-amino-5-phosphonovaleric acid (AP5), or both, and recovery conditions. In neurons receiving AP and ADN inputs, NBQX attenuated AP- and ADN-evoked responses by 46 (P = 0.0206) and 49% (P = 0.0042). AP5 attenuated AP- and ADN-evoked responses by 39 (P = 0.0270) and 40% (P = 0.0157). NBQX + AP5 attenuated AP- and ADN-evoked responses by 74 (P = 0.0040) and 75% (P = 0.0028). In neurons receiving AP and vagal inputs, AP transmission was attenuated by 58, 60, and 98%; vagal transmission was attenuated by 62, 35, and 83% during NBQX, AP5, and both antagonists, respectively. These data suggest that both non-NMDA and NMDA receptors transmit AP input to NTS neurons in aortic baroreceptor or vagal afferent pathways. |
| Starting Page | 47 |
| Ending Page | 51 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ajpheart.physiology.org/content/ajpheart/275/5/H1695.full.pdf |
| PubMed reference number | 9815077v1 |
| Volume Number | 275 |
| Issue Number | 5 |
| Part | 2 |
| Journal | The American journal of physiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Abducens Nerve Diseases Afferent Pathways Aspartic Acid Cell Nucleus Chloralose Forty Nine Glutamic Acid N-Methyl-D-Aspartate Receptors N-Methylaspartate Neurons Nucleus solitarius Pressoreceptors Rabbits Structure of area postrema Thioctic Acid Vagus nerve structure |
| Content Type | Text |
| Resource Type | Article |
