NDLI: Rat small mesenteric artery function after hindlimb suspension.

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Rat small mesenteric artery function after hindlimb suspension.

Content Provider	Semantic Scholar
Author	Looft-Wilson, Robin C. Gisolfi, Carl V.
Copyright Year	2000
Abstract	To determine whether simulated microgravity in rats is associated with vascular dysfunction, we measured responses of isolated, pressurized mesenteric resistance artery segments (157- to 388-microm ID) to vasoconstrictors, pressure, and shear stress after 28-day hindlimb suspension (HS). Results indicated no differences between HS and control (C) groups in 1) sensitivity or maximal responses to vasoconstrictors (norepinephrine, phenylephrine, serotonin, KCl); 2) ID, external diameter, or ratio of wall thickness to ID; 3) distensibility; or 4) vasodilatory responses to shear stress. Myogenic tone was attenuated (P < 0.05) in HS arteries vs. C, as evidenced by 1) decreased magnitude of tone in larger vessels (second-order branch off superior mesenteric artery, 261- to 388-microm ID) at pressures >/=40 mmHg in the presence of phenylephrine (10(-7) M) and 2) decreased magnitude of tone in smaller vessels (third-order branch off superior mesenteric artery, 157- to 277-microm ID), which exhibited spontaneous tone, at pressures > or =70 mmHg. This attenuation of myogenic tone after HS could contribute to orthostatic intolerance because myogenic tone contributes to the overall tone of resistance arteries.
Starting Page	1107
Ending Page	1107
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jap.physiology.org/content/jap/88/4/1199.full.pdf
PubMed reference number	10749808v1
Volume Number	88
Issue Number	4
Journal	Journal of applied physiology
Language	English
Access Restriction	Open
Subject Keyword	Arterial system Blood Vessel Cerebrovascular Disorders Diameter (qualifier value) Greater Hindlimb Suspension Lower Extremity Mesenteric Arteries Mesentery Norepinephrine Phenylephrine Potassium Chloride Serotonin Small Superior mesenteric artery structure Suspensions Vasoconstrictor Agents shear stress torr
Content Type	Text
Resource Type	Article

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