NDLI: Differential long-lasting potentiation of the NMDA and non-NMDA synaptic currents induced by metabotropic and NMDA receptor coactivation in cerebellar granule cells.

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Differential long-lasting potentiation of the NMDA and non-NMDA synaptic currents induced by metabotropic and NMDA receptor coactivation in cerebellar granule cells.

Content Provider	Semantic Scholar
Author	Rossi, Paola D'Angelo, Egidio Taglietti, Vanni
Copyright Year	1996
Abstract	UNLABELLED Whole-cell patch-clamp recordings in rat cerebellar slices were used to investigate the effect of metabotropic glutamate receptor activation on mossy fibre-granule cell synaptic transmission. Transient application of 20 microM 1S, 3R-aminocyclopentane-1, 3-dicarboxylic acid simultaneously with low-frequency NMDA receptor activation induced long-lasting non-decremental potentiation of both NMDA and non-NMDA receptor-mediated synaptic transmission. Potentiation could be prevented by application of the metabotropic glutamate receptor antagonist (+)-O-methyl-4-carboxyphenyl-glycine at 500 microM. Characteristically, NMDA potentiation was two to three times as large as non-NMDA current potentiation, occurred only in a slow subcomponent, and was voltage-independent. This result demonstrates a pivotal role of NMDA receptors in the metabotropic potentiation of transmission, which may be important in regulating cerebellar information processing. KEYWORDS cerebellum, LTP, metabotropic receptors, NMDA receptors, patch-clamp, rat
Starting Page	17
Ending Page	26
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www-5.unipv.it/dangelo/wp-content/uploads/n-Rossi1996.pdf
PubMed reference number	8752588v1
Volume Number	8
Issue Number	6
Journal	The European journal of neuroscience
Language	English
Access Restriction	Open
Subject Keyword	Cortical Cell Layer of the Cerebellum Excitatory Amino Acid Antagonists Glutamate Receptor Glutamic Acid Long-Term Potentiation N-Methyl-D-Aspartate Receptors N-Methylaspartate Receptor Activation Process Receptors, Metabotropic Glutamate Synaptic Transmission Thioctic Acid chemosensitization/potentiation glycine N-methyltransferase granule cell voltage
Content Type	Text
Resource Type	Article

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