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Induction of NMDA receptor-dependent long-term depression in visual cortex does not require metabotropic glutamate receptors.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sawtell, Nathaniel Huber, Kimberly M. |
| Copyright Year | 1999 |
| Abstract | We tested the role of group I mGluRs in the induction of long-term depression (LTD) in the visual cortex, using the novel mGluR antagonist LY341495 and mice lacking mGluR5, the predominant phosphoinositide (PI)-linked mGluR in the visual cortex. We find that LY341495 is a potent blocker of glutamate-stimulated PI hydrolysis in visual cortical synaptoneurosomes, and that it effectively antagonizes the actions of the mGluR agonist 1S, 3R-aminocyclopentane-1,3-dicarboxylic acid (ACPD) on synaptic transmission in visual cortical slices. However, LY341495 has no effect on the induction of LTD by low-frequency stimulation. Furthermore, mice lacking mGluR5 show normal NMDA receptor-dependent LTD. These results indicate that group I mGluR activation is not required for the induction of NMDA receptor-dependent LTD in the visual cortex. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://bearlab-s1.mit.edu/BearLab/pubs/sawtell99.pdf |
| Alternate Webpage(s) | http://jn.physiology.org/content/jn/82/6/3594.full.pdf |
| Alternate Webpage(s) | http://bearlab-s1.mit.edu/bearlab/pubs/sawtell99.pdf |
| PubMed reference number | 10601487v1 |
| Volume Number | 82 |
| Issue Number | 6 |
| Journal | Journal of neurophysiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 1-amino-1,3-dicarboxycyclopentane Cerebral cortex Depressive disorder Glutamate Receptor Glutamic Acid LY 341495 Long-Term Synaptic Depression N-Methyl-D-Aspartate Receptors N-Methylaspartate Phosphatidylinositols Receptors, Metabotropic Glutamate Synaptic Transmission Thioctic Acid |
| Content Type | Text |
| Resource Type | Article |
