NDLI: Effects of androstenedione on long term potentiation in the rat dentate gyrus: Relevance for affective and degenerative diseases

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Effects of androstenedione on long term potentiation in the rat dentate gyrus: Relevance for affective and degenerative diseases

Content Provider	Semantic Scholar
Author	Schwartz, Michal Harris, John Lewis Chu, Luis Gijsbers, Karel Dubrovsky, Bernardo
Copyright Year	2002
Abstract	We studied the effects of the androgenic hormone androstenedione, a 17-ketosteroid, on long term potentiation (LTP) in the dentate gyrus (DG) of intact, urethane anesthetized rats. Intravenous injection of 10mg of the hormone dissolved in Nutralipid produced a significant increase of the population spike (PS), but not of the excitatory post-synaptic potentials (EPSPs). The results are discussed in terms of the potential enhancement that androstenedione may have on some aspects of memory processes as reported for other androgenic steroids. Also noted are the plausible beneficial effects of the hormone on depression as well as in recovery following both central and peripheral neural injury.
Starting Page	207
Ending Page	211
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/S0361-9230(02)00781-5
PubMed reference number	12127019
Journal	Medline
Volume Number	58
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0361923002007815
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0361923002007815?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0361-9230%2802%2900781-5
Journal	Brain Research Bulletin
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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