NDLI: Long-term potentiation in the dentate gyrus: Effects of noradrenaline depletion in the awake rat

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Long-term potentiation in the dentate gyrus: Effects of noradrenaline depletion in the awake rat

Content Provider	Semantic Scholar
Author	Robinson, Gilbert B. Racine, Ronald J.
Copyright Year	1985
Abstract	The chronic rat preparation was utilized to study the effects of noradrenaline (NA) depletion on field potentials recorded from the hilus of the fascia dentata. Both single pulses and high-frequency trains were applied to the perforant path (PP). The effects of NA depletion on baseline responses as well as on long-term potentiation (LTP) were examined. Reduced NA levels resulted in an increase in the population spike amplitude and a depression of the population excitatory postsynaptic potential (EPSP). Depleted animals showed significantly higher levels of LTP of the population EPSP, but reduced levels of population spike LTP (measured 13-15 min after tetanization). There were, however, no differences in LTP levels 1 week after the potentiation tests. These results demonstrate that NA levels do not affect that component of LTP which can persist for several weeks.
Starting Page	71
Ending Page	78
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1016/0006-8993(85)90303-8
PubMed reference number	2983834
Journal	Medline
Volume Number	325
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0006899385903038
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0006899385903038?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0006-8993%2885%2990303-8
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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