NDLI: Avaliação De Danos Ao Dna Em Tecidos De Ratos Wistar Com Hiperlipidemia Induzida Por Tiloxapol

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Avaliação De Danos Ao Dna Em Tecidos De Ratos Wistar Com Hiperlipidemia Induzida Por Tiloxapol

Content Provider	Semantic Scholar
Author	Hoffmann, Cleonice Bondan, Juliana Fachini, Jean Unfer, Julia Pereira Sousa, Joubert Aires De Picada, Jaqueline Nascimento
Copyright Year	2017
Abstract	A hiperlipidemia, caracterizada por niveis elevados de triglicerideos no plasma e LDL-colesterol, acompanhada de niveis reduzidos de colesterol HDL, esta frequentemente associada a um risco aumentado de doencas cardiovasculares. No entanto, poucos estudos tem mostrado os efeitos da hiperlipidemia na estabilidade genomica. O objetivo deste estudo foi avaliar os danos ao DNA causados pela hiperlipidemia induzida por tiloxapol. A instabilidade genomica foi avaliada em ratos Wistar, utilizando o ensaio cometa e o teste de micronucleos. As analises bioquimicas confirmaram hiperlipidemia em ratos tratados com tiloxapol, acompanhada de hiperglicemia. Niveis elevados de creatinina e ureia foram observados, sugerindo lesao renal. O ensaio cometa indicou um aumento dos danos ao DNA em sangue, figado e rins, mas nao no tecido cerebral. No entanto, nao houve aumento na frequenciado micronucleos. Esses achados indicam que a hiperlipidemia induzida por tiloxapol e capaz de aumentar a instabilidade genomica, o que esta associada com maior risco de câncer. Portanto, este surfactante pode ser usado em modelos para avaliar novos farmacos hipolipidemicos com propriedades quimiopreventivas associadas.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.eventos.ulbra.br/index.php/eucf/eucf3/paper/viewFile/2599/1235
Alternate Webpage(s)	http://www.eventos.ulbra.br/index.php/eucf/eucf3/paper/viewFile/2599/1173
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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