Danos ao DNA promovidos por ácido 5-aminolevulínico: possível associação com o desenvolvimento de carcinoma hepatocelular em portadores de porfiria aguda intermitente

Content Provider	Semantic Scholar
Author	Onuki, J. Teixeira, Priscila Camillo Medeiros, Marisa H. G. Mascio, Paolo Di
Copyright Year	2002
Abstract	5-Aminolevulinic acid (ALA) is a heme precursor accumulated in acute intermittent porphyria (AIP), which might be associated with hepatocellular carcinoma (HCC) in symptomatic patients. Under metal catalyzed oxidation, ALA and its cyclic dimerization product, 3,6-dihydropyrazine-2,5-dipropanoic acid, produce reactive oxygen species that damage plasmid and calf thymus DNA bases, increase the steady state level of 8-oxo-7,8-dihydro-2´-deoxyguanosine in liver DNA and promote mitochondrial DNA damage. The final product of ALA, 4,5-dioxovaleric acid (DOVA), is able to alkylate guanine moieties, producing adducts. ALA and DOVA are mutagenic in bacteria. This review shows an up-to-date literature data that reinforce the hypothesis that the DNA damage induced by ALA may be associated with the development of HCC in AIP patients.
Starting Page	594
Ending Page	608
Page Count	15
File Format	PDF HTM / HTML
DOI	10.1590/S0100-40422002000400015
Volume Number	25
Alternate Webpage(s)	http://quimicanova.sbq.org.br/imagebank/pdf/Vol25No4_594_14.pdf
Alternate Webpage(s)	https://doi.org/10.1590/S0100-40422002000400015
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article