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Synthesis, characterization and cytotoxicity appraisal of original 1, 2, 3-Triazole derivatives, against breast cancer cell lines (MDA-MB-231)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mohammed, Mohammed Khalaf Al-Shuhaib, Zainab Al-Shawi, Ali A. A. |
| Copyright Year | 2019 |
| Abstract | The present study established the efficient separate synthesis of four unique 1, 2, 3-triazole derivatives (M1, M2, M3, M4) via conducting 1,3-dipolar cycloaddition of N-((4-azidophenyl) sulfonyl) acetamide, with substituted N-phenylmaleimide. FTIR, 1H NMR, 13C NMR, and mass spectra were utilized for the characterization of the triazoles. The cytotoxic activities of these compounds, with regards to breast cancer cell lines (MDA-MB-231), were then evaluated. The cytotoxicity pre-screening outcomes for 100 µM portrayed a variety of actions, while the IC50 values with concentrations of 0-500 µM for 48 hours, the results are 2.542, 2.929, 2.429, and 2.864 µM for the compounds M1, M2, M3, and M4 respectively. Remarkably, the M2 and M4 para -substituted compounds exhibited superior IC50 values, in comparison to the M1 and M3 ortho -substituted compounds. This suggests that the M1 and M3 compounds have the potential to perform as against breast cancer. |
| Starting Page | 305 |
| Ending Page | 310 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.13171/mjc941911161021mkm |
| Volume Number | 9 |
| Alternate Webpage(s) | http://www.medjchem.com/index.php/medjchem/article/download/1021/769 |
| Alternate Webpage(s) | https://doi.org/10.13171/mjc941911161021mkm |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
