Evaluation of curcumin for cytotoxicity potential on MDA-MB-231 cancer cell lines

Content Provider	Semantic Scholar
Author	Rashmi, Rashmi Prakash, Nagarkatti Narayanaswamy, Hogalagere Doddappaih Swamy, M. Narayana Rathnamma, D. Ramesh, Padma Sunilchandra, U. Naveenkumar, S. Kumar, Kr Anjan Vanishree, H.
Copyright Year	2020
Abstract	Natural compounds have gained a promising role in both cancer prevention and therapy. They play an important role in the discovery of lead compounds and represent an excellent source of novel anticancer drugs. Curcumin is a renowned natural compound derived from the rhizome Curcuma longa L, commonly known as turmeric. In the present study, the cytotoxicity potential of curcumin on MDA-MB231 cell lines was determined by MTT [3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide] assay. It was conducted at 48h incubation to determine percent cell viability. The IC50 value of curcumin was 18.54μM. The curcumin showed dose-dependent cytotoxicity on triple-negative breast cancer cells. The in vitro cytotoxicity potential of curcumin in terms of percent cell viability proved to be relatively effective on triple-negative breast cancer cells.
Starting Page	270
Ending Page	272
Page Count	3
File Format	PDF HTM / HTML
Volume Number	8
Alternate Webpage(s)	http://www.entomoljournal.com/archives/2020/vol8issue1/PartE/8-1-62-100.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article