NDLI: Existe relaciÓn entre la enfermedad de Alzheimer y defectos en el ADN mitocondrial

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Existe relaciÓn entre la enfermedad de Alzheimer y defectos en el ADN mitocondrial

Content Provider	Semantic Scholar
Author	Rodriguez-Santiago, Benjamin Casademont, Jordi Nunes, Virginia
Copyright Year	2001
Abstract	Introduction. Various studies have related Alzheimer's disease (AD) with mitochrondrial defects. These defects may be structural, biochemical or genetic in type. Amongst the genetic defects the rearrangement and particular mutations described in mitochondrial DNA (mtDNA) are striking. Objective. To study the incidence of rearrangement and 4 particular mutations in the mtDNA of patients with AD, and determine the possible differences from persons taken as controls. Patients and methods. Necropsies of the cerebellum, frontal cortex and hippocampus of patients with AD and controls. We also used blood from living patients diagnosed as having EA and from controls. The samples were analysed using hybrid Southern blot with a mitochondrial probe. Particular mutations G3196A, A3397G, A4336G and G5460A/T were also analysed. Results. No differences were found between the patients and controls, in either brain tissue or blood on analysis using Southern. No association was found between the particular mutations analysed and the AD of our samples. Conclusions. The results obtained did not support the hypothesis of involvement of mitochondria in AD. Regarding rearrangement and the 4 particular mutations analysed in the mtDNA of our samples. However, this does not rule out the possible existence of other particular mutations which were not analysed and/or other mitochondrial defects which contribute to the development of A AD.
Starting Page	301
Ending Page	305
Page Count	5
File Format	PDF HTM / HTML
Volume Number	33
Alternate Webpage(s)	http://diposit.ub.edu/dspace/bitstream/2445/135182/1/194309.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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