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Comparison of hypersensitivity reactions to PEG-asparaginase in children after intravenous and intramuscular administration.
| Content Provider | Semantic Scholar |
|---|---|
| Author | August, Keith J. Miller, W. P. Dalton, Amanda Shinnick, Sara E. |
| Copyright Year | 2013 |
| Abstract | INTRODUCTION Polyethylene-glycolated (PEG)-asparaginase (PEG-ASP) is a crucial component of pediatric acute lymphoblastic leukemia therapy. Although hypersensitivity reactions to PEG-ASP occur less frequently than with other formulations, they are not uncommon and have an adverse impact on patient outcomes. Intravenous (IV) administration of PEG-ASP reduces patient pain and anxiety and is being used with increasing frequency in children. MATERIALS AND METHODS A retrospective review was performed to compare the incidence of hypersensitivity reactions to PEG-ASP in children when administered either by intramuscular (IM) or IV routes between January 2006 and May 2008. RESULTS Of 68 patients studied, 7 experienced a hypersensitivity reaction (10.3%). Two of 16 patients (12.5%) who received only IV PEG-ASP and 3 of 27 patients (11.1%) exposed to only IM PEG-ASP experienced a hypersensitivity reaction. Severe reactions (grade 3 or 4) occurred only once after 119 total doses (0.8%) of IV PEG-ASP and once after 215 total doses (0.5%) of IM PEG-ASP (P=1.0). Thrombosis or pancreatitis were rare and were not increased after IV PEG-ASP administration. DISCUSSION IV PEG-ASP is well tolerated and does not result in a significant increase in the incidence of hypersensitivity reactions in children. |
| Starting Page | 93 |
| Ending Page | 109 |
| Page Count | 17 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.slaop.org/pdf/84432.Asparaginase%20Comparison%20of%20Hypersensitivity%20Reactions%20to%20PEGAsparaginase%20in%20Children%20After%20Intravenous%20and%20Intramuscular%20Administration.pdf |
| PubMed reference number | 23619117v1 |
| Alternate Webpage(s) | https://doi.org/10.1097/MPH.0b013e31828e5471 |
| DOI | 10.1097/mph.0b013e31828e5471 |
| Journal | Journal of pediatric hematology/oncology |
| Volume Number | 35 |
| Issue Number | 7 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | ASPARAGINASE Anxiety Disorders Aspirate substance Drug Allergy Glycolates Hypersensitivity Leukemia, Lymphocytic, Acute, L1 Pain Pancreatitis Patients Polyethylene Glycols Precursor Cell Lymphoblastic Leukemia Lymphoma Thrombosis lymphoblast pegaspargase peginterferon alfa-2b |
| Content Type | Text |
| Resource Type | Article |
