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Inflammation and cytokeratin 7/20 staining of cardiac mucosa in young patients with and without Helicobacter pylori infection.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Oksanen, Aino Mirjam Sankila, Anna Boguslawski, Kristina Von Sipponen, Pentti Ilmari Rautelin, Hilpi |
| Copyright Year | 2005 |
| Abstract | BACKGROUND Both Helicobacter pylori and gastro-oesophageal reflux disease (GORD) may cause inflammation in cardiac mucosa. Intestinal metaplasia (IM) is found more often in GORD associated inflammation than in inflammation caused by H pylori, especially in young individuals. AIM To examine morphological differences in chronic inflammation in these two conditions by immunohistochemistry. PATIENTS/METHODS Tissue blocks from cardiac mucosa of patients <45 years were available as follows: 10 patients with chronic inflammation of cardiac mucosa (carditis) and H pylori gastritis (group 1); 10 patients with (possibly GORD related) carditis, but normal antrum and corpus (group 2); and 10 patients with non-inflamed cardiac mucosa and normal antrum and corpus (group 3). Haematoxylin and eosin staining and immunohistochemical staining for various inflammatory cells were performed for patients in groups 1 and 2 as follows: CD20 (B cells), CD3 (T cells), CD4 (T helper cells), CD8 (T suppressor cells), CD163 (macrophages), CD138 (plasma cells), and CD117 (mast cells). For all patients, cytokeratin 7/20 (CK7/20) staining was performed. RESULTS No clear differences were seen in the morphology of chronic inflammation between groups 1 and 2. In both, plasma cells were most abundant. CK7/20 staining showed no differences between these groups. CONCLUSION Helicobacter pylori negative (possibly GORD associated) and H pylori related carditis cannot be distinguished on a morphological basis. The stronger tendency towards IM in the first entity cannot be explained by differences in the type of inflammation. Barrett-type CK7/20 staining seems typical for cardiac mucosa, irrespective of the type of inflammation or presence of IM. |
| Starting Page | 197 |
| Ending Page | 205 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jcp.bmj.com/content/jclinpath/58/4/376.full.pdf |
| PubMed reference number | 15790701v1 |
| Volume Number | 58 |
| Issue Number | 4 |
| Journal | Journal of clinical pathology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antrum Artificial cardiac pacemaker Body of uterus Body tissue CDISC SDTM Gastrointestinal Test Name Terminology Carditis Cytokeratin Eosine Yellowish Gastritis Gastroesophageal reflux disease Helicobacter pylori infection Helper-Inducer T-Lymphocyte Hematoxylin Mucous Membrane Patients Staining method T-helper cell type 1 intestinal metaplasia mast cell |
| Content Type | Text |
| Resource Type | Article |
