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Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kondamudi, Phani Krishna Kovelamudi, Hemalatha Mathew, Geetha Nayak, Pawan G. Rao, Chamallamudi Mallikarjuna Shenoy, Rekha R. |
| Copyright Year | 2013 |
| Abstract | BACKGROUND Inflammatory bowel disease (IBD) is a chronic inflammatory condition of gastrointestinal tract of immune, genetic and environmental origin. In the present study, we examined the effect of sesamol (SES), the main anti-oxidative constituent of Sesamum indicum (sesame seed) Linn. in the dinitrochlorobenzene (DNCB)-induced model for IBD in rats. METHODS The groups were divided into normal control, DNCB control, SES and sulfasalazine (SS). On day 24, the rats were killed, colon removed and the macroscopic, biochemical and histopathological evaluations were performed. RESULTS The levels of MPO, TBARS and nitrite increased significantly (p < 0.05) in the DNCB group, whereas reduced significantly in the SES, SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. IL-6 and TNF-α levels were significantly high in the DNCB group. CONCLUSIONS We conclude the mucosal protective effect of SES on colon due to its potent antioxidant actions. Further investigation is required in a chronic model of different rodent strain for its role involved in the cytokine pathway. |
| Starting Page | 3107 |
| Ending Page | 3118 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://rabbit.if-pan.krakow.pl/pjp/pdf/2013/3_658.pdf |
| Alternate Webpage(s) | http://www.if-pan.krakow.pl/pjp/pdf/2013/3_658.pdf |
| Alternate Webpage(s) | http://rabbit.if-pan.krakow.pl/pjp/pdf/2013/3_658_ab.pdf |
| Alternate Webpage(s) | http://www.if-pan.krakow.pl/pjp/pdf/2013/3_658_ab.pdf |
| PubMed reference number | 23950588v1 |
| Volume Number | 65 |
| Issue Number | 3 |
| Journal | Pharmacological reports : PR |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Dinitrochlorobenzene Evaluation Gastrointestinal tract structure Inflammatory Bowel Diseases Intestinal Diseases Intestines Irritable Bowel Syndrome Mucous Membrane Nitrite Measurement Nitrites Sesamum Sulfasalazine Thiobarbituric Acid Reactive Substances cytokine sesamol |
| Content Type | Text |
| Resource Type | Article |
