Loading...
Please wait, while we are loading the content...
Similar Documents
Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sastraruji, Kwankamol Sastraruji, Thanapat Pyne, Stephen G. Ung, Alison T. Jatisatienr, Araya Lie, Wilford |
| Copyright Year | 2010 |
| Abstract | Semisynthesis of the known Stemona alkaloids oxystemofoline (7) and methoxystemofoline (8) has been achieved starting from (11Z)-1',2'-didehydrostemofoline (6), which confirmed their structures and absolute configurations. The synthesis of (1'R)-hydroxystemofoline (9) helped establish this compound as a natural product from Stemona aphylla. (1'S)-Hydroxystemofoline (10) and a number of related analogues were also prepared. In a TLC bioautographic assay, 9 was found to be the most active acetylcholinesterase inhibitor, but it was not as active as galanthamine. |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/np100137h |
| PubMed reference number | 20415428 |
| Journal | Medline |
| Volume Number | 73 |
| Issue Number | 5 |
| Alternate Webpage(s) | http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2206&context=scipapers |
| Alternate Webpage(s) | https://ro.uow.edu.au/cgi/viewcontent.cgi?article=2206&context=scipapers |
| Alternate Webpage(s) | https://doi.org/10.1021/np100137h |
| Journal | Journal of natural products |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |