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Long-lived states to sustain SABRE hyperpolarised magnetisation† †Electronic supplementary information (ESI) available: Experimental details, sample specification, substrate characterisation, SABRE studies, pulse sequence details, simulations. See DOI: 10.1039/c6cp02844f Click here for additional da
| Content Provider | Semantic Scholar |
|---|---|
| Author | Roy, Soumya S. Rayner, Peter Norcott, Philip Green, Gary G. R. Duckett, Simon B. |
| Copyright Year | 2016 |
| Abstract | The applicability of the magnetic resonance (MR) technique in the liquid phase is limited by poor sensitivity and short nuclear spin coherence times which are insufficient for many potential applications. Here we illustrate how it is possible to address both of these issues simultaneously by harnessing long-lived hyperpolarised spin states that are formed by adapting the Signal Amplification by Reversible Exchange (SABRE) technique. We achieve more than 4% net 1H-polarisation in a long-lived form that remains detectable for over ninety seconds by reference to proton pairs in the biologically important molecule nicotinamide and a pyrazine derivative whose in vivo imaging will offer a new route to probe disease in the future. |
| Starting Page | 24905 |
| Ending Page | 24911 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c6cp02844f |
| PubMed reference number | 27711398 |
| Journal | Medline |
| Volume Number | 18 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c6/cp/c6cp02844f/c6cp02844f1.pdf |
| Alternate Webpage(s) | https://pubs.rsc.org/en/content/articlepdf/2016/cp/c6cp02844f |
| Alternate Webpage(s) | http://eprints.whiterose.ac.uk/104071/1/PCCP_Paper_Revised_final.pdf |
| Alternate Webpage(s) | http://pubs.rsc.org/en/content/articlepdf/2016/cp/c6cp02844f |
| Alternate Webpage(s) | https://doi.org/10.1039/c6cp02844f |
| Journal | Physical chemistry chemical physics : PCCP |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |