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On the phylogenetic placement of human T cell leukemia virus type 1 sequences associated with an Andean mummy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Coulthart, Michael B. Posada, David Crandall, Keith A. Dekaban, Gregory A. |
| Copyright Year | 2006 |
| Abstract | Recently, the putative finding of ancient human T cell leukemia virus type 1 (HTLV-1) long terminal repeat (LTR) DNA sequences in association with a 1500-year-old Chilean mummy has stirred vigorous debate. The debate is based partly on the inherent uncertainties associated with phylogenetic reconstruction when only short sequences of closely related genotypes are available. However, a full analysis of what phylogenetic information is present in the mummy data has not previously been published, leaving open the question of what precisely is the range of admissible interpretation. To fulfill this need, we re-analyzed the mummy data in a new way. We first performed phylogenetic analysis of 188 published LTR DNA sequences from extant strains belonging to the HTLV-1 Cosmopolitan clade, using the method of statistical parsimony which is designed both to optimize phylogenetic resolution among sequences with little evolutionary divergence, and to permit precise mapping of individual sequence mutations onto branches of a divergence network. We then deduced possible phylogenetic positions for the two main categories of published Chilean mummy sequences, based on their published 157-nucleotide LTR sequences. The possible phylogenetic placements for one of the mummy sequence categories are consistent with a modern origin. However, one of these placements for the other mummy sequence category falls very close to the root of the Cosmopolitan clade, consistent with an ancient origin for both this mummy sequence and the Cosmopolitan clade. |
| Starting Page | 1416 |
| Ending Page | 1419 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://darwin.uvigo.es/download/papers/39.mummyHTLV06.pdf |
| PubMed reference number | 16503510v1 |
| Volume Number | 6 |
| Issue Number | 2 |
| Journal | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Accidental Falls Adult T-Cell Lymphoma/Leukemia Categories Cellular Phone Chronic Lymphocytic Leukemia Clinical act of insertion Departure - action Genotype How True Feel Vigorous Right Now Human T-lymphotropic virus 1 Leukemia, B-Cell Long Terminal Repeat Mummies Murine sarcoma viruses Mutation Scientific Publication Terminal Repeat Sequences |
| Content Type | Text |
| Resource Type | Article |
