NDLI: miR-490-3p functions as a tumor suppressor in glioma by inhibiting high-mobility group AT-hook 2 expression

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miR-490-3p functions as a tumor suppressor in glioma by inhibiting high-mobility group AT-hook 2 expression

Content Provider	Semantic Scholar
Author	Zhang, Fang Wu, Anhao Wang, Yinhui Liu, Jianmin
Copyright Year	2019
Abstract	Glioma is one of the most common types of malignant cancer and the significance of microRNAs (miRNAs) in cancer therapy has been demonstrated. In the current study, miR-490-3p expression was significantly downregulated in glioma tissue and cell lines. Overexpression of miR-490-3p inhibited glioma cell proliferation and migration in vitro. In addition, the high-mobility group AT-hook 2 (HMGA2) was identified as a candidate target gene of miR-490-3p. The current study demonstrated that miR-490-3p mimic could inhibit HMGA2 protein expression in glioma cells. In addition, correlation analysis demonstrated that miR-490-3p and HMGA2 expression was inversely correlated in glioma tissues. Furthermore, the inhibitory effect of miR-490-3p mimic on cell proliferation and migration was partially reversed by the overexpression of HMGA2. Taken together, these results suggest that miR-490-3p may have a tumor suppressive role in glioma and therefore miR-490-3p may be a new target for the treatment of glioma.
Starting Page	664
Ending Page	670
Page Count	7
File Format	PDF HTM / HTML
DOI	10.3892/etm.2019.7606
PubMed reference number	31258704
Journal	Medline
Volume Number	18
Alternate Webpage(s)	https://www.spandidos-publications.info/etm/18/1/664/download
Alternate Webpage(s)	https://doi.org/10.3892/etm.2019.7606
Journal	Experimental and therapeutic medicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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