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Mu and delta opioid receptor-like immunoreactivity in the cervical spinal cord of the rat after dorsal rhizotomy or neonatal capsaicin: an analysis of pre- and postsynaptic receptor distributions
| Content Provider | Semantic Scholar |
|---|---|
| Author | Abbadie, Catherine Lombard, Marie-Christine Besson, Jean-Marie Trafton, Jodie A. Basbaum, Allan I. |
| Copyright Year | 2002 |
| Abstract | Opioid compounds have powerful analgesic properties when administered to the spinal cord. These effects are exerted through mu and delta opioid receptors, and both pre- and postsynaptic mechanisms have been implicated. To specifically address the relative pre- and postsynaptic contribution to spinal opioid analgesia, we have quantitatively assessed the pre- vs. postsynaptic distribution of the mu-opioid (MOR-1, MOP(1)) and delta-opioid receptors (DOR-1, DOP(1)). We also examined the rostro-caudal arborization of MOR-1 and DOR-1 immunoreactive primary sensory neurons, using an isolated dorsal root preparation. These results were compared to those obtained by labeling for calcitonin gene-related peptide (CGRP), a neuropeptide whose expression in the spinal cord is restricted to the terminals of small diameter primary sensory neurons. We estimate that approximately one half of MOR-1 and two thirds of DOR-1 immunoreactivity in the cervical spinal cord is located on primary afferent fibers. These fibers have a broad rostro-caudal distribution, extending at least three segments rostral and caudal to their segment of entry. Regardless of marker used, the rostral projection was greatest, however, the distribution of CGRP-immunoreactive fibers differed somewhat in that they had a much smaller projection to the most caudal segments examined. Our results suggest that presynaptic delta opioid actions predominate, but that there are mixed pre- and postsynaptic inhibitory effects exerted by opioid analgesics that act at the spinal cord mu opioid receptor. |
| Starting Page | 150 |
| Ending Page | 162 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0006-8993(02)02242-4 |
| PubMed reference number | 11879805 |
| Journal | Medline |
| Volume Number | 930 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0006899302022424 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0006899302022424?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0006-8993%2802%2902242-4 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
