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Diagnostic and Prognostic Relevance of Bone Marrow Microenvironment Components in Non Hodgkin’s Lymphoma Cases Before and After Therapy
| Content Provider | Semantic Scholar |
|---|---|
| Author | Soliman, Amira H. |
| Copyright Year | 2016 |
| Abstract | Objective: To evaluate stromal cells of the bone marrow microenvironment (BMM) in bone marrow trephine biopsy (BMTB) specimens, with a focus on fibronectin, tumor necrosis factor- alpha (TNF-α) and L-selectin in Non- Hodgkin’s lymphoma (NHL) patients, before and after therapy. Materials and Methods: A total of 80 de novo NHL patients, 64 with B-cell lymphomas 80% , (follicular cell lymphoma (FCL) in 32, chronic lymphocytic leukemia/ small lymphocytic lymphoma (CLL/SLL) in 12, and diffuse large cell lymphoma in 20) and 16 with T-cell lymphomas (20%) all diagnosed as T-Lymphoblastic lymphomas, were evaluated before and after therapy. For comparison, 25 age and sex matched BM donors, were included as a control group. BMTB material and BM aspirates were taken for morphological assessment of stromal cells, the plasma of these samples being examined for TNFα and L-selectin by ELISA, and fibronectin by radial immunodiffusion (RID). Results: BM stromal cells comprising reticular macrophages and fibroblasts were elevated in 53.3% of NHL cases at diagnosis, while BM fibronectin levels were decreased and BM TNFα and L-selectin were higher than in controls (p<0.05). In NHL cases, elevated values of BM TNFα and BM L-selectin were associated with signs of aggressive disease, including >1 extra nodal sites, detectable B symptoms, high grade, BM and CNS invasion, and a high International prognostic index (IPI) (p<0.05). Conclusion: BMM components, TNFα, L-selectin and fibronectin, in NHL can be useful in evaluating disease activity, extent and response to treatment and as prognostic markers according to the IPI. |
| Starting Page | 5273 |
| Ending Page | 5280 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://journal.waocp.org/article_42294_9aa29a4fdf1ecb254bd12b79a4f2a3b2.pdf |
| Alternate Webpage(s) | http://scholar.cu.edu.eg/sites/default/files/amirahsoliman/files/bone_marrow_microenvironment_components_in_nhl_before_and_after_treatment_1.pdf |
| PubMed reference number | 28125873 |
| Volume Number | 17 |
| Journal | Asian Pacific journal of cancer prevention : APJCP |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aspirate substance B-Cell Lymphomas Bone Marrow Diseases Chronic Lymphocytic Leukemia Diffuse Large B-Cell Lymphoma Eighty Enzyme-Linked Immunosorbent Assay Immunodiffusion measurement International Prognostic Index L-Selectin Lymphoma, Large-Cell, Follicular Lymphoma, Non-Hodgkin Patients Precursor Cell Lymphoblastic Leukemia Lymphoma Precursor cell lymphoblastic lymphoma Radial Immunodiffusion Reticulosarcoma Selectins Small Lymphocytic Lymphoma Specimen Stromal Cells T-Cell Lymphoma TREPHINE tumor necrosis |
| Content Type | Text |
| Resource Type | Article |
