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Tambussi Immunotherapy in HIV disease : recent developments and future directions
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nozza, Silvia Pizzocolo, Cecilia Pogliaghi, Manuela Torre, Liviana Della Lazzarin, Adriano |
| Copyright Year | 2009 |
| Abstract | Use of highly active antiretroviral therapy (HAART) has changed the natural history of HIV infection decreasing mortality and morbidity [1]. Clinical improvement is due to qualitative and quantitative immune reconstitution after control of viral replication. Despite use of HAART, we are not able to fully reconstitute immune competence [2]. The goal of immunotherapy strategies (cytokines, therapeutic vaccines or immunomodulators), is to accelerate or improve the immune restoration and/or control of viral replication in association with cART or after its interruption. At the state of knowledge, it is clear that the decline of CD4 is only partially explained by the level of viral load; host factors and the degree of immune activation, play an essential role in the immunodeficiency. On the other hand, the level of immune restoration achieved with cART reduces AIDS events, but is not enough to obtain of mortality and morbidity rate close to the general population, except for patients with prolonged high CD4 T levels (> 500/mm3). Adjuvant immunotherapy with cytokines has been proposed as the ideal approach to modulate immune response by directly targeting the immune system. Intermittent treatment with Interleukin-2 (IL-2). |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.mnlpublimed.com/public/HA02-A05.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
