NDLI: Doppler velocimetry in fetal rats exposed to enoxaparin and unfractionated heparin (UFH) during pregnancy.

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Doppler velocimetry in fetal rats exposed to enoxaparin and unfractionated heparin (UFH) during pregnancy.

Content Provider	Semantic Scholar
Author	Senefonte, Flávio Renato De Almeida Aydos, Ricardo Dutra Oliveira, Vanessa Marcon De Bósio, Marco Antonio Costa Figueiró-Filho, Ernesto A.
Copyright Year	2017
Abstract	Purpose: To evaluate the effects of enoxaparin and unfractionated heparin (UFH) administered in prophylactic and therapeutic doses on fetal vessels in healthy pregnant Wistar rats, according to Doppler velocimetry measurements. Methods: Fifty animals were assigned to one of five groups: controls (saline), prophylactic and therapeutic enoxaparin (1 and 2 mg/kg/day, respectively), and prophylactic and therapeutic UFH (72 and 400 UI/kg/day, respectively). Uterine horns were examined by ultrasound for identification of live fetuses. A sample of these fetuses underwent Doppler velocimetry. Spectral curves, peak systolic velocity (PSV), pulsatility index (PI), and resistance index (RI) of the middle cerebral artery, ductus venosus, and umbilical artery were investigated. Differences were considered statistically significant when p<0.05. Results: No significant differences in PSV, PI, or RI values were observed among the groups. Conclusion: Doppler velocimetry measurements revealed no significant effects of enoxaparin or unfractionated heparin on fetal vessels in pregnant Wistar rats.
Starting Page	325
Ending Page	333
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.scielo.br/pdf/acb/v32n5/1678-2674-acb-32-05-00325.pdf
PubMed reference number	28591361v1
Alternate Webpage(s)	https://doi.org/10.1590/s0102-865020170050000001
DOI	10.1590/s0102-865020170050000001
Journal	Acta cirurgica brasileira
Volume Number	32
Issue Number	5
Language	English
Access Restriction	Open
Subject Keyword	Blood Vessel Body mass index Condoms, Unspecified Enoxaparin Fetus Heart Failure, Systolic Horns PersonNameUse - assigned Structure of cerebral artery Structure of ductus venosus Structure of middle cerebral artery Structure of umbilical artery Thyroid Hormone Resistance Syndrome Umbilicus (Anatomy) heparin
Content Type	Text
Resource Type	Article

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Doppler velocimetry in fetal rats exposed to enoxaparin and unfractionated heparin (UFH) during pregnancy

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