NDLI: Scar and pulmonary expression and shedding of ACE in rat myocardial infarction.

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Scar and pulmonary expression and shedding of ACE in rat myocardial infarction.

Content Provider	Semantic Scholar
Author	Gaertner, Roger F. Prunier, Fabrice Philippe, Monique Louedec, Liliane Mercadier, J. L. Michel, Jean-Baptiste
Copyright Year	2002
Abstract	We examined the topology of angiotensin-converting enzyme (ACE) mRNA expression, activity, and shedding in myocardial infarction-induced heart failure and sought to elucidate the source of the increased plasma ACE activity in this model. Three months after coronary ligature, lung, scar, and remaining viable left ventricular tissues were analyzed for ACE mRNA expression as well as tissue and solubilized ACE activity. ACE mRNA expression increased in the scar with respect to infarct severity, decreased in the lung, and remained unchanged in the left ventricle. ACE activity decreased in the lung and increased in the scar tissue and plasma. Shedding of ACE remained constant in the lung and increased in the scar. This study shows that ACE expression and activity is shifted from the pulmonary endothelium to the infarct scar tissue and that constancy of shedding in the lung and its increase in the scar are the source of the increased plasma ACE in congestive heart failure.
Starting Page	6 pp.
Ending Page	6 pp.
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ajpheart.physiology.org/content/ajpheart/283/1/H156.full.pdf
Alternate Webpage(s)	http://ajpheart.physiology.org/content/early/2002/03/21/ajpheart.00848.2001.full.pdf
PubMed reference number	12063286v1
Volume Number	283
Issue Number	1
Journal	American journal of physiology. Heart and circulatory physiology
Language	English
Access Restriction	Open
Subject Keyword	Anatomy, Regional Angiotensins Body tissue Caspase-1 Cicatrix Heart Ventricle Heart failure Left ventricular structure Ligation Myocardial Infarction Structure of parenchyma of lung
Content Type	Text
Resource Type	Article

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