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Bifidobacterium-Rich Fecal Donor May Be a Positive Predictor for Successful Fecal Microbiota Transplantation in Patients with Irritable Bowel Syndrome.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mizuno, Shinta Masaoka, Tatsuhiro Naganuma, Makoto Kishimoto, Taishiro Kitazawa, Momoko Kurokawa, Shunya Nakashima, Moeko Takeshita, Kozue Suda, Wataru Mimura, Masaru Hattori, Masahira Kanai, Takanori |
| Copyright Year | 2017 |
| Abstract | BACKGROUND/AIMS Dysbiosis is associated with various systemic disorders including irritable bowel syndrome (IBS). Fecal microbiota transplantation (FMT) might restore intestinal microbial balance. The study aimed to determine the safety and efficacy of FMT in IBS patients, as well as also positive predictors for FMT. METHODS This was a single-arm, open-label study. Eligible patients were diagnosed based on Rome III Diagnostic Criteria. Fecal materials were administered to the patient via colonoscopy. The primary end point was a change in the Bristol stool form scale at 4 weeks after FMT. Recovery to types 3-4 was considered a clinical response. The secondary end point was a change in intestinal microbiota and psychological status using the Hamilton Rating Scale. RESULTS Ten patients were enrolled. Six patients achieved a clinical response. The diversity of patients 4 weeks after FMT increased significantly compared with patients before FMT, and that of responding patients was significantly higher than non-responder patients. The abundance of Bifidobacterium in effective donors was significantly higher than in ineffective donors and patients. Psychological status of all patients was significantly improved after FMT. CONCLUSIONS FMT for patients with IBS is safe, and relatively effective. Bifidobacterium-rich fecal donor may be a positive predictor for successful FMT. Key Summary: (1) Dysbiosis is associated with various gastrointestinal disorders including IBS. (2) FMT has potential to restore intestinal microbial balance. (3) We showed that FMT improved stool form and psychological status of IBS patients. (4) Bifidobacterium-rich donor efficiently induced symbiosis in IBS patients. |
| Starting Page | 29 |
| Ending Page | 38 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.karger.com/Article/Pdf/471919 |
| PubMed reference number | 28628918v1 |
| Alternate Webpage(s) | https://doi.org/10.1159/000471919 |
| DOI | 10.1159/000471919 |
| Journal | Digestion |
| Volume Number | 96 |
| Issue Number | 1 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bifidobacterium Dysbiosis Fecal Microbiota Transplantation Feces Gastrointestinal Diseases Intestinal Microbiome Intestines Irritable Bowel Syndrome Microbiota (plant) Patients Symbiosis Temporomandibular Joint Disorders diagnostic criteria |
| Content Type | Text |
| Resource Type | Article |
