NDLI: Reversed-Phase High Performance Liquid Chromatographic Method for the Simultaneous Analysis of Four Benzodiazepines in Pharmaceutical Formulations

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Reversed-Phase High Performance Liquid Chromatographic Method for the Simultaneous Analysis of Four Benzodiazepines in Pharmaceutical Formulations

Content Provider	Semantic Scholar
Author	Thangadurai, Subbiah Kanagaraj, B. R. Kulantheswaran, Maniraj
Copyright Year	2015
Abstract	Benzodiazepines (BZD) are widely used in pharmacotherapy as antiepileptics, muscle relaxant, hypnotic, and anaesthetic inductors. Because of the increasing number of pharmaceutical preparations of BZD, these drugs are frequently encountered in clinical and forensic case work samples involving road traffic offences and/or drug overdoses. Also, BZDs are now among the most commonly-prescribed drugs, which increase their potential for addiction and abuse, and often they are found in combination with other drugs in drug-related fatalities or drug facilitated sexual assault cases. For these reasons, the analysis of BZDs is of great interest to forensic and clinical toxicologists. A reversed phase high performance liquid chromatographic method for the simultaneous analysis of four frequently prescribed BZDs (alprazolam, chlordiazepoxide, diazepam and nitrazepam) in bulk powder or formulated in tablets. Isocratic elution at a flow rate of 1.0 and 1.5 mL min was employed on a symmetry Flexar Quartenary column C18 (250 mm x 4.6 mm, 5μ) at ambient temperature. The four different mobile phase systems were studied. The UV detection wavelength was at 254 nm and 10 μL sample was injected. The excipients present in tablets and capsules did not interfere with the developed method. The developed method is rapid and sensitive, and is suitable for routine control of pharmaceutical dosage forms and it could be applied to the forensic samples.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.forensics.org.my/pdf/fssmVol.6No.1/Article%2003.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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