Loading...
Please wait, while we are loading the content...
Similar Documents
Evaluation of a live attenuated recombinant virus RAV 9395 as a herpes simplex virus type 2 vaccine in guinea pigs.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Spector, F. C. Kern, Earl R. Palmer, Jane Kaiwar, Ravi Cha, T. A. Brown, Pamela Spaete, Richard R. |
| Copyright Year | 1998 |
| Abstract | Recombinant virus RAV 9395 was constructed by deleting both copies of the gamma(1)34.5 gene, and the UL55 and UL56 open reading frames from herpes simplex virus type 2 (HSV-2) strain G. The potential use of RAV 9395 as an HSV-2 vaccine was investigated by evaluating the ability of RAV 9395 to protect guinea pigs from severe disease by HSV-2(G) challenge. RAV 9395 administered intramuscularly reduced both lesion development and severity in a dose-dependent manner in guinea pigs challenged with HSV-2(G). The frequency of reactivation of RAV 9395 from explanted dorsal root ganglia was low compared with that of HSV-2(G). Immunization with RAV 9395 at doses of 1 x 10(5) pfu and above generally precluded the establishment of latency by the challenge virus. The results presented in this report lend support for the development of genetically engineered live HSV vaccines. |
| Starting Page | 70 |
| Ending Page | 73 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jid/177/5/10.1086/515278/2/177-5-1143.pdf?Expires=1492603625&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=gC5Edl~NcmW51iKj0HfxA7ybIxWauuHEhG0zVuJjqa7yYxoBUZyoN7xDtYXxrUnraL9ZtiIOdoPQNF4xksHxsxMAhIiQwFXmGOurOHVBin1Q5mNqzD-dfNfNFX9Kc-Se6qRyHAwWrvUnYpjHUCufJWTE5uJ3smmn9bkliRCIE8eRg5wYgKvUm794shIZ38UmrRNhG6kA6QTauORPF7fhckF1x1EoywhkbAfatDPpDlPklNYoJEbjgZh7JZGFTGLB1TtNkgf-YWd6YY1WXzxCJHl0NOsWWRn7QEbHYKt97DdrOgNAiqV3S-jN~-d1JXSRLopiJXB2axPjv74oZKpcLQ__ |
| PubMed reference number | 9592996v1 |
| Volume Number | 177 |
| Issue Number | 5 |
| Journal | The Journal of infectious diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cavia Copy (object) Frame (physical object) Ganglia Ganglia, Spinal Genetic Engineering Herpes Simplex Infections Human Herpesvirus 2 Open Reading Frames Plaque Forming Unit Posterior root of spinal nerve Reactivation Reading Frames (Nucleotide Sequence) Recombinants Simplexvirus recombinant virus |
| Content Type | Text |
| Resource Type | Article |
