NDLI: Apparent stability of herpes simplex virus genomes isolated from primary and recurrent infections and dorsal root ganglia in the mouse.

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Apparent stability of herpes simplex virus genomes isolated from primary and recurrent infections and dorsal root ganglia in the mouse.

Content Provider	Semantic Scholar
Author	Blondeau, J. M. Embil, Juan A.
Copyright Year	1988
Abstract	Following natural or experimental primary infection, herpes simplex virus (HSV) becomes latent in sensory ganglia. Reactivation of latent virus may lead to recurrent disease. If HSV DNA remains stable during primary, recurrent and latent infections, that stability would enable us to trace the transmission of HSV from one individual to another. We inoculated mice in the ear pinna with HSV and collected virus at various intervals during primary infection. In mice surviving primary infections, recurrent disease was induced from which virus was isolated. Virus was also recovered from explanted dorsal root ganglia. Virus isolates were characterised by restriction endonuclease digestion and compared with the original inoculate(s). The data indicate that in all cases except two, the isolates from primary and recurrent infections remained identical to the original inoculates.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.microbiologyresearch.org/docserver/fulltext/jmm/27/4/medmicro-27-4-291.pdf?accname=guest&checksum=B0AD5F8DC62F239EA947745BDA03B11C&expires=1539622401&id=id
Alternate Webpage(s)	http://www.microbiologyresearch.org/docserver/fulltext/jmm/27/4/medmicro-27-4-291.pdf?accname=guest&checksum=17D9B818313D6161318BA1E269187708&expires=1540447423&id=id
PubMed reference number	2848947v1
Volume Number	27
Issue Number	4
Journal	Journal of medical microbiology
Language	English
Access Restriction	Open
Subject Keyword	Auricle of external ear Deciduous tooth Ganglia Ganglia, Sensory Ganglia, Spinal Genome Herpes Simplex Infections Infection Latent Virus Posterior root of spinal nerve Recurrent disease Simplexvirus endonuclease
Content Type	Text
Resource Type	Article

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