NDLI: Differentially expressed genes responsible for insensitivity of CD34+ cells to kinase inhibitors in patients with chronic myeloid leukemia

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Differentially expressed genes responsible for insensitivity of CD34+ cells to kinase inhibitors in patients with chronic myeloid leukemia

Content Provider	Semantic Scholar
Author	Moreira-Nunes, Caroline Fa Azevedo, Tereza Cb Beltrão, Ana Cs Francês, Larissa Tvm Sousa, Rodrigo Gma Silva, Israel T. Da Silva, Artur Silva, Wilson Araújo Lemos, José Ar
Copyright Year	2013
Abstract	Background Chronic Myeloid Leukemia (CML) is a clonal myeloproliferative disorder characterized by formation of BCR-ABL fusion that encodes the p210 oncoprotein, which has a tyrosine kinase activity that confers an adaptive advantage to leukemic cells. Imatinib mesylate (IM) acts specifically on p210. Imatinib is able to reduce the differentiated cells (CD66b+) efficiently, but it has not the same effect on the stem cells (CD34+), which can be kept alive during treatment. Our aim was to identify expressed genes in CD34+ and CD66b+ cells as candidates for kinase inhibitors transport.
Starting Page	O1
Ending Page	O1
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://bmcproc.biomedcentral.com/track/pdf/10.1186/1753-6561-7-S2-O1?site=bmcproc.biomedcentral.com
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/93/8b/1753-6561-7-S2-O1.PMC3624121.pdf
PubMed reference number	3624121
Volume Number	7
Language	English
Access Restriction	Open
Subject Keyword	Binding corporate rules Chronic electrode implant Clone Fusion Proteins, bcr-abl Imatinib mesylate Leukemia, Myelocytic, Acute Mesylates Myeloid Leukemia Myeloid Leukemia, Chronic Myeloproliferative disease Oncogene Proteins OpenEdge Advanced Business Language (ABL) Patients Protein Tyrosine Kinase Stem cells
Content Type	Text
Resource Type	Article

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