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Incidence and predictors of reCurrent restenosis after drug-coated balloon Angioplasty for Restenosis of a drUg-eluting Stent: The ICARUS Cooperation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cassese, Salvatore Habara, Seiji Rittger, Harald Byrne, Robert A. Waliszewski, Matthias W. Pérez-Vizcayno, María José Gao, Run-Lin Kastrati, Adnan Alfonso, F. Perez Iñigo |
| Copyright Year | 2018 |
| Abstract | INTRODUCTION AND OBJECTIVES The incidence and predictors of recurrent restenosis after drug-coated balloon (DCB) angioplasty for drug-eluting stent (DES) restenosis remain poorly studied. We sought to evaluate the incidence and predictors of recurrent restenosis among participants in randomized controlled trials receiving DCB angioplasty for DES restenosis. METHODS The clinical and lesion data of individuals enrolled in 6 randomized controlled trials of DCB angioplasty for DES restenosis were pooled. All patients included in this report were assigned to receive paclitaxel-coated balloon angioplasty with the SeQuent Please DCB (B Braun, Melsungen, Germany). The current analysis focused on participants with available follow-up angiography at 6 to 9 months. The incidence of recurrent restenosis, defined as diameter restenosis ≥ 50% in the in-segment area at follow-up angiography, and its clinical and angiographic predictors were evaluated. RESULTS A total of 546 patients were combined in a single dataset. Angiographic follow-up at 6 to 9 months was available for 484 patients (88.6%) with 518 treated lesions. Recurrent restenosis was detected in 101 (20.8%) patients. On multivariable analysis, lesion length (OR, 1.58; 95%CI, 1.10-2.26; P=.012 for 5mm increase) and vessel size (OR, 1.42; 95%, 1.12-1.79; P=.003 for 0.5mm reduction) were independently associated with recurrent restenosis. CONCLUSIONS In the largest cohort to date of individuals with angiographic surveillance after DCB angioplasty for DES restenosis, we demonstrated that recurrent restenosis occurs in approximately 1 out of 5 patients. Predictors of recurrent restenosis are increased lesion length and small vessel size. |
| Starting Page | 620 |
| Ending Page | 627 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.rec.2017.08.005 |
| PubMed reference number | 28916429 |
| Journal | Medline |
| Volume Number | 71 |
| Issue Number | 8 |
| Alternate Webpage(s) | https://www.revespcardiol.org/index.php?p=revista&pii=S1885585717303936&tipo=pdf-simple |
| Alternate Webpage(s) | https://multimedia.elsevier.es/PublicationsMultimediaV1/item/multimedia/S0300893217305171:mmc1.pdf?idApp=UINPBA000025 |
| Alternate Webpage(s) | https://multimedia.elsevier.es/PublicationsMultimediaV1/item/multimedia/S1885585717303936:mmc1.pdf?idApp=UINPBA000025 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.rec.2017.08.005 |
| Journal | Revista espanola de cardiologia |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
