NDLI: Simultaneous detection of changes in perfusion and BOLD contrast.

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Simultaneous detection of changes in perfusion and BOLD contrast.

Content Provider	Semantic Scholar
Author	Schwarzbauer, Christian
Copyright Year	2000
Abstract	A new functional magnetic resonance imaging (fMRI) technique for simultaneous detection (SIDE) of changes in perfusion and blood oxygenation level dependent (BOLD) contrast is described. Perfusion contrast is generated by using magnetically labeled endogenous water proton spins as a freely diffusible tracer. A single slice-selective inversion pulse is combined with dual echo echo-planar imaging to generate a spin-echo (SE) image sensitive to changes in perfusion and a gradient-echo (GE) image sensitive to changes in both perfusion and BOLD contrast. The SIDE technique was applied to detect functional changes induced by a visual search task. A theoretical analysis is provided to calculate quantitative maps of changes in cerebral blood flow (DeltaCBF) and effective transverse relaxation time (DeltaT(2)) from the corresponding signal changes in the SE and GE images. Since SE an GE images are generated from the same longitudinal magnetization, no errors due to spatial or temporal mismatch can arise in the quantification of DeltaCBF and DeltaT(2).
Starting Page	37
Ending Page	42
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://cds.ismrm.org/ismrm-1999/PDF6/1743.pdf
PubMed reference number	10668052v1
Volume Number	13
Issue Number	1
Journal	NMR in biomedicine
Language	English
Access Restriction	Open
Subject Keyword	Cell Respiration Cerebrovascular Circulation Dual Echo-Planar Imaging Gradient Magnetic Resonance Imaging Protons Quantitation Tracer Transverse Spin Relaxation Time blood oxygen level dependent fMRI
Content Type	Text
Resource Type	Article

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