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Human CD8⁺ and CD4⁺ T cell memory to lymphocytic choriomeningitis virus infection.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kotturi, Maya F. Swann, Justine A. Peters, Bjoern Arlehamn, Cecilia S. Lindestam Sidney, John Kolla, Ravi V. James, Eddie A. Akondy, Rama S. Ahmed, Rafi Kwok, William W. Buchmeier, Michael J. Sette, Alessandro |
| Copyright Year | 2011 |
| Abstract | Although cellular immunity to acute lymphocytic choriomeningitis virus (LCMV) infection has been well characterized in experimental studies in mice, the T cell response to this virus in humans is incompletely understood. Thus, we analyzed the breadths, magnitudes, and differentiation phenotypes of memory LCMV-specific CD8(+) and CD4(+) T cells in three human donors displaying a variety of disease outcomes after accidental needle stick injury or exposure to LCMV. Although only a small cohort of donors was analyzed at a single time point postinfection, several interesting observations were made. First, we were able to detect LCMV-specific CD8(+) and CD4(+) T cell responses directly ex vivo at 4 to 8 years after exposure, demonstrating the longevity of T cell memory in humans. Second, unlike in murine models of LCMV infection, we found that the breadths of memory CD8(+) and CD4(+) T cell responses were not significantly different from one another. Third, it seemed that the overall CD8(+) T cell response was augmented with increasing severity of disease, while the LCMV-specific CD4(+) T cell response magnitude was highly variable between the three different donors. Next, we found that LCMV-specific CD8(+) T cells in the three donors analyzed seemed to undergo an effector memory differentiation program distinct from that of CD4(+) T cells. Finally, the levels of expression of memory, costimulatory, and inhibitory receptors on CD8(+) and CD4(+) T cell subsets, in some instances, correlated with disease outcome. These data demonstrate for the first time LCMV-specific CD8(+) and CD4(+) T cells in infected humans and begin to provide new insights into memory T cell responses following an acute virus infection. |
| Starting Page | 119 |
| Ending Page | 202 |
| Page Count | 84 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jvi.asm.org/content/85/22/11770.full.pdf |
| PubMed reference number | 21900169v1 |
| Alternate Webpage(s) | https://doi.org/10.1128/JVI.05477-11 |
| DOI | 10.1128/JVI.05477-11 |
| Journal | Journal of virology |
| Volume Number | 85 |
| Issue Number | 22 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | CDISC SDTM Disease Outcome Terminology Cellular Immunity Cellular Phone Chronic Lymphocytic Leukemia Epstein-Barr Virus Infections Leukemia, B-Cell Lymphocytic choriomeningitis virus Memory Disorders Murine sarcoma viruses Needlestick Injuries Phenotype |
| Content Type | Text |
| Resource Type | Article |
