NDLI: CD8 T Cell Cross-Reactivity Networks Mediate Heterologous Immunity in Human EBV and Murine Vaccinia Virus Infections

Please wait, while we are loading the content...

CD8 T Cell Cross-Reactivity Networks Mediate Heterologous Immunity in Human EBV and Murine Vaccinia Virus Infections

Content Provider	Scilit
Author	Cornberg, Markus Clute, Shalyn C. Watkin, Levi B. Saccoccio, Frances M. Kim, Sung-Kwon Naumov, Yuri N. Brehm, Michael A. Aslan, Nuray Welsh, Raymond M. Selin, Liisa K.
Copyright Year	2010
Description	In this study, we demonstrate complex networks of CD8 T cell cross-reactivities between influenza A virus and EBV in humans and between lymphocytic choriomeningitis virus and vaccinia virus in mice. We also show directly that cross-reactive T cells mediate protective heterologous immunity in mice. Subsets of T cell populations reactive with one epitope cross-reacted with either of several other epitopes encoded by the same or the heterologous virus. Human T cells specific to EBV-encoded $BMLF1_{280–288}$ could be cross-reactive with two influenza A virus or two other EBV epitopes. Mouse T cells specific to the vaccinia virus-encoded $a11r_{198–205}$ could be cross-reactive with three different lymphocytic choriomeningitis virus, one Pichinde virus, or one other vaccinia virus epitope. Patterns of cross-reactivity differed among individuals, reflecting the private specificities of the host's immune repertoire and divergence in the abilities of T cell populations to mediate protective immunity. Defining such cross-reactive networks between commonly encountered human pathogens may facilitate the design of vaccines.
Ending Page	2838
Page Count	14
Starting Page	2825
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.0902168
Alternate Webpage(s)	http://www.jimmunol.org/content/184/6/2825.full.pdf
Journal	The Journal of Immunology
Issue Number	6
Volume Number	184
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2010-03-15
Access Restriction	Open
Subject Keyword	Vaccinia Virus Epstein Barr Virus Influenza A Virus Lymphocytic Choriomeningitis Virus Memory Cd8 T-cells Cross-reactivity Heterologous Immunity Infectious Mononucleosis
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

CD8 T-cell cross-reactivity networks mediate heterologous immunity in human Epstein-Barr (EBV) and murine vaccinia (VV) virus infections

This information is current as EBV and Murine Vaccinia Virus Infections Mediate Heterologous Immunity in Human CD 8 T Cell Cross-Reactivity Networks

Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires.

Resistance to Vaccinia Virus Is Less Dependent on TNF under Conditions of Heterologous Immunity

Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires

Human CD8⁺ and CD4⁺ T cell memory to lymphocytic choriomeningitis virus infection.

Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion

Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-MHC structural features recognized by cross-reactive T cells.

The CD8 T Cell-Epstein-Barr Virus-B Cell Trialogue: A Central Issue in Multiple Sclerosis Pathogenesis

CD8 T Cell Cross-Reactivity Networks Mediate Heterologous Immunity in Human EBV and Murine Vaccinia Virus Infections

Similar Documents

CD8 T-cell cross-reactivity networks mediate heterologous immunity in human Epstein-Barr (EBV) and murine vaccinia (VV) virus infections

This information is current as EBV and Murine Vaccinia Virus Infections Mediate Heterologous Immunity in Human CD 8 T Cell Cross-Reactivity Networks

Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires.

Resistance to Vaccinia Virus Is Less Dependent on TNF under Conditions of Heterologous Immunity

Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires

Human CD8⁺ and CD4⁺ T cell memory to lymphocytic choriomeningitis virus infection.

Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion

Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-MHC structural features recognized by cross-reactive T cells.

The CD8 T Cell-Epstein-Barr Virus-B Cell Trialogue: A Central Issue in Multiple Sclerosis Pathogenesis

CD8 T Cell Cross-Reactivity Networks Mediate Heterologous Immunity in Human EBV and Murine Vaccinia Virus Infections