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Annonaceous acetogenins: recent progress.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Alali, Feras Q. Liu, Xiangyu McLaughlin, Jerry |
| Copyright Year | 1999 |
| Abstract | The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms. This review presents the progress made in the chemistry, biology, and development of these compounds since December 1995. |
| Starting Page | 48 |
| Ending Page | 54 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.pawpawresearch.com/acetogenins19991.pdf |
| PubMed reference number | 10096871v1 |
| Volume Number | 62 |
| Issue Number | 3 |
| Journal | Journal of natural products |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adenosine Triphosphate Annonaceae Annonaceous Acetogenins Fatty Acids Inhibition NADH Neoplasms Plasma membrane |
| Content Type | Text |
| Resource Type | Article |