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Prepregnancy body mass index, vaginal inflammation, and the racial disparity in preterm birth.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Simhan, Hyagriv N. Bodnar, Lisa M. |
| Copyright Year | 2006 |
| Abstract | The authors sought to quantify the overall and race/ethnic-specific relations between prepregnancy body mass index and both preterm birth and vaginal inflammation. Data from a cohort of 11,392 women who enrolled in the multicenter Vaginal Infections and Prematurity Study (1984-1989) at 23-26 weeks' gestation were used. Compared with a prepregnancy body mass index of 22, a body mass index of 16 increased the risk of preterm birth by 90% (odds ratio = 1.9, 95% confidence interval (CI): 1.5, 2.6), and a body mass index of 18 increased the risk by 40% (odds ratio = 1.4, 95% CI: 1.2, 1.7). Ethnicity substantially modified the magnitude of the body mass index effect and the shape of the preterm birth risk curve, with underweight having a greater impact on preterm birth among Blacks and Hispanics than among Whites. Low body mass index increased the risk of a high level of neutrophils (> 5 per oil immersion field) and a high vaginal pH measurement (> or = 5.0) among Black women; for a body mass index of 16 versus 22, the odds ratio = 1.7 (95% CI: 1.1, 2.6). Compared with Black women with a body mass index of 22, Blacks with a body mass index of 16 had a 1.7-fold increased risk for a high level of neutrophils and a high vaginal pH measurement, while those with a body mass index of 18 had a 1.3-fold increased risk. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/aje/163/5/10.1093/aje/kwj053/2/kwj053.pdf?Expires=1498684550&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=KJ4yHAbnCrBeKKoaWnv4MNY~j3TFLwUxx~UHN6NzExctnqWzsc~FzLk93ArAaJAkxyKYYHM3IeiUs~6HjQml~lekE5StntUL0IYCAOqf-D-bKoZvKjvQWAsY1-dbDqxCQypNTF4wYGFJKTfHn~eapsVqUr1LBzO-JoRYwuBES0W4NqGGH4Z6GXb6yVNG1EJuEYHNct2eObaYFsZKrrA9BqnFS5MTFj4E6~edB881v4NhpB13Ka9hKrKoYZKhiJEgYk0AdjLQJNqBinTB4atlghUk8JfM9BfeGUiPW1PNa1s0sK8HII-0L94--R3C3rH4tdkNHIpx0Dv4xBbdDPqu5Q__ |
| PubMed reference number | 16394203v1 |
| Volume Number | 163 |
| Issue Number | 5 |
| Journal | American journal of epidemiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Birth Injuries Body mass index Confidence Intervals Contraceptive methods Infection Odds Ratio Pregnancy Premature Obstetric Labor Vagina Vaginal Dosage Form Vaginal Hemorrhage Vaginitis |
| Content Type | Text |
| Resource Type | Article |