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Synthesis, DNA-binding and photocleavage studies of ruthenium(II) complexes [Ru(btz)3]2+ and [Ru(btz)(dppz)2]2+
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yu, Hui-Juan Huang, Shu-Mei Kou, Jun-Feng Li, Lv-Ying Jia, Hai-Na Chao, Hui Ji, Liang-Nian |
| Copyright Year | 2009 |
| Abstract | Two new ruthenium(II) complexes, [Ru(btz)3](ClO4)2 (1) and [Ru(btz)(dppz)2](ClO4)2 (2) (btz = 4,4′-bithiazole, dppz = dipyrido[3,2-a:2′,3′-c]phenazine), have been synthesized and characterized by elemental analysis, 1H NMR, ES-MS and X-ray crystallography. The DNA binding behaviors of two complexes have been studied by spectroscopic and viscosity measurements. The results suggest that complex 1 binds to CT-DNA via an electrostatic mode, while complex 2 via an intercalative mode. Under irradiation at 365 nm, both complexes were found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form I to nicked form II. The mechanism studies reveal that singlet oxygen 1O2 and hydroxyl radical (OH.) play a significant role in the photocleavage process. |
| Starting Page | 1504 |
| Ending Page | 1511 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s11426-009-0206-9 |
| Volume Number | 52 |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1007/s11426-009-0206-9 |
| Alternate Webpage(s) | https://doi.org/10.1007/s11426-009-0206-9 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
