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Ensayo terapéutico con dosis oral única de pamoato de pirantel en las infecciones por Enterobius vermicularis y Ascaris lumbricoides
| Content Provider | Semantic Scholar |
|---|---|
| Author | Noemí, Isabel Reyes, Hernán Abeliuk, O. Mauro, G. Astorga, Berbeli |
| Copyright Year | 1975 |
| Abstract | RESUMEN Mediante dosis oral uruca de 10 mg por Kg de peso corporal se tralan con pamoato de pirantel 75 casos de enterobiasis y 13 casos de ascariasis diagnosticados mediante frotis anal seriado (5 muestras) y por examen seriado de heces (3 muestras), respectivamente. Todos los pacientes jueron sometidos a control parasitologic, en igual forma que para el diagnostico inicial, a los 7 y 30 dias despues del tratamiento. Considerando como curadas solo a las personas cuyos exdmenes fue-ron persistentemente negativos, se obtuvo un tn-dice global de curacion parasitologica correspon-dienie a 92,3% en ascariasis y a 84,0% en enterobiasis. La tolerancia de la droga fue excelen-te y solo el 5,7%) de los casos presento leves y fugaces molestias atribuibles a ella. SUMMARY Seventy five patients with enterobiasis and thirteen with ascariasis were treated with a single oral dose of pyrantel pamoate, 10 mg per body weight Infections diagnosis was made through 5 serial Graham perianal scotch-tape samples and examination of 3 serial stool specimens respectively. All patients were submitted for pa-rasitological control with the same diagnostic procedures at 7 and 30 days after treatment. Only those people who showed both controls to be negative were considered as cured. Parasitological cure rates were 92,3% for ascariasis and 84,0% for enterobiasis. Only 5,7% of patients exhibited mild and short side effects with the drug used. REFERENCIAS 1.— Austin, W.C., Courtney, W., Danilewicz, JC, Morgan, D.H., Conover. L.H., Howes, H.L. Jr., Lanch, 7.E., Mc Farfond, J.W., Cornwell, R.L. and Theo-dorides, V.J. Pyrantel tartrate. A new anthelmintic effective against infections of domestic animals. Nature, 212: 1273-1274, 1966. 2.— Cornwell, R.L. Controlled laboratory trials in sheep with anthelmintic pyrantel tartrate. Vet. Rec, 79: 590-595, 1966. 3.— Cornwell, R.L. Field trials in sheep with the anthelmintic pyrantel tartrate. Comparative trials in the prevention of Nematodirus infection in lambs. Vet. Rec, 79: 626-629, 1966. 4.— Howes, H.L. and Lynch, J.E. Anthelmintic studies with pyrantel. I. Therapeutic and prophylactic efficacy against the enteral stages of various helminths in mice and dogs. J. Parasitol., 53- 1085-1091, 1967. 5.— Cornwell, R.L. and Jones, RM.. Anthelm |
| Starting Page | 107 |
| Ending Page | 110 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.4067/S0370-41061975000200003 |
| Volume Number | 46 |
| Alternate Webpage(s) | https://scielo.conicyt.cl/pdf/rcp/v46n2/art03.pdf |
| Alternate Webpage(s) | https://doi.org/10.4067/S0370-41061975000200003 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
