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High-intensity aerobic interval training increases fat and carbohydrate metabolic capacities in human skeletal muscle.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Perry, Christopher G. R. Heigenhauser, George J. F. Bonen, Arend Spriet, Lawrence L. |
| Copyright Year | 2008 |
| Abstract | High-intensity aerobic interval training (HIIT) is a compromise between time-consuming moderate-intensity training and sprint-interval training requiring all-out efforts. However, there are few data regarding the ability of HIIT to increase the capacities of fat and carbohydrate oxidation in skeletal muscle. Using untrained recreationally active individuals, we investigated skeletal muscle and whole-body metabolic adaptations that occurred following 6 weeks of HIIT (~1 h of 10 x 4 min intervals at ~90% of peak oxygen consumption (VO2 peak), separated by 2 min rest, 3 d.week-1). A VO2 peak test, a test to exhaustion (TE) at 90% of pre-training VO2 peak, and a 1 h cycle at 60% of pre-training VO2 peak were performed pre- and post-HIIT. Muscle biopsies were sampled during the TE at rest, after 5 min, and at exhaustion. Training power output increased by 21%, and VO2 peak increased by 9% following HIIT. Muscle adaptations at rest included the following: (i) increased cytochrome c oxidase IV content (18%) and maximal activities of the mitochondrial enzymes citrate synthase (26%), beta-hydroxyacyl-CoA dehydrogenase (29%), aspartate-amino transferase (26%), and pyruvate dehydrogenase (PDH; 21%); (ii) increased FAT/CD36, FABPpm, GLUT 4, and MCT 1 and 4 transport proteins (14%-30%); and (iii) increased glycogen content (59%). Major adaptations during exercise included the following: (i) reduced glycogenolysis, lactate accumulation, and substrate phosphorylation (0-5 min of TE); (ii) unchanged PDH activation (carbohydrate oxidation; 0-5 min of TE); (iii) ~2-fold greater time during the TE; and (iv) increased fat oxidation at 60% of pre-training VO2 peak. This study demonstrated that 18 h of repeated high-intensity exercise sessions over 6 weeks (3 d.week-1) is a powerful method to increase whole-body and skeletal muscle capacities to oxidize fat and carbohydrate in previously untrained individuals. |
| File Format | PDF HTM / HTML |
| DOI | 10.1139/H08-097 |
| PubMed reference number | 19088769 |
| Journal | Medline |
| Volume Number | 33 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://biologiemartinbolduc.mbolduc1.profweb.ca/wp-content/uploads/2011/09/Perryetal-2008.pdf |
| Alternate Webpage(s) | https://www.firstprotein.co.uk/HIIT-Scientific-bumf.pdf |
| Alternate Webpage(s) | https://doi.org/10.1139/H08-097 |
| Journal | Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
