NDLI: An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle.

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An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle.

Content Provider	Semantic Scholar
Author	Little, Jonathan Peter Safdar, Adeel Bishop, David Tarnopolsky, Mark A. Gibala, Martin J.
Copyright Year	2011
Abstract	Low-volume, high-intensity interval training (HIT) increases skeletal muscle mitochondrial capacity, yet little is known regarding potential mechanisms promoting this adaptive response. Our purpose was to examine molecular processes involved in mitochondrial biogenesis in human skeletal muscle in response to an acute bout of HIT. Eight healthy men performed 4 × 30-s bursts of all-out maximal intensity cycling interspersed with 4 min of rest. Muscle biopsy samples (vastus lateralis) were obtained immediately before and after exercise, and after 3 and 24 h of recovery. At rest, the majority of peroxisome proliferator-activated receptor γ coactivator (PGC)-1α, a master regulator of mitochondrial biogenesis, was detected in cytosolic fractions. Exercise activated p38 MAPK and AMPK in the cytosol. Nuclear PGC-1α protein increased 3 h into recovery from exercise, a time point that coincided with increased mRNA expression of mitochondrial genes. This was followed by an increase in mitochondrial protein content and enzyme activity after 24 h of recovery. These findings support the hypothesis that an acute bout of low-volume HIT activates mitochondrial biogenesis through a mechanism involving increased nuclear abundance of PGC-1α.
Starting Page	7
Ending Page	7
Page Count	1
File Format	PDF HTM / HTML
DOI	10.1152/ajpregu.00538.2010
PubMed reference number	21451146
Journal	Medline
Volume Number	300
Issue Number	6
Alternate Webpage(s)	http://ajpregu.physiology.org/content/ajpregu/early/2011/03/25/ajpregu.00538.2010.full.pdf
Alternate Webpage(s)	https://doi.org/10.1152/ajpregu.00538.2010
Journal	American journal of physiology. Regulatory, integrative and comparative physiology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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