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Prognostic value of PD-L1 in esophageal squamous cell carcinoma: a meta-analysis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Guo, Wei Wang, Pan Li, Ning Shao, Fei Zhang, Hao Yang, Zhenlin Li, Renda Gao, Yibo He, Jie |
| Copyright Year | 2015 |
| Abstract | Accumulated evidence has shown that the programmed cell death receptor 1/programmed cell death receptor 1 ligand 1 (PD-1/PD-L1) pathway is a promising therapeutic target for cancer immunotherapy. However, the association between PD-L1 and esophageal squamous cell carcinoma (ESCC) patient survival remains unclear. We performed a meta-analysis to investigate the prognostic value of PD-L1 in ESCC. We searched PubMed, Embase, Web of Knowledge, and Cochrane Central Register of Controlled Trials databases for relevant studies that evaluated PD-L1 expression and ESCC patient survival. Fixed- and random-effects meta-analyses were conducted according to the heterogeneity of the included studies. Sensitivity analysis was performed according to Metan-based influence analysis. Publication bias was evaluated using Egger's and Begg's tests. Overall, 13 studies with 2,877 patients were included. Twelve studies demonstrated the association between overall survival (OS), and 6 studies described the relation between disease-free survival (DFS). PD-L1 overexpression was found in 43.7% (1,258 of 2,877) of the patients with ESCC. High PD-L1 expression was associated with distant metastasis in patients with ESCC (P = 0.04). Moreover, high PD-L1 expression was significantly associated with poor OS (hazard ratio [HR] 1.38, 95% confidence interval [CI] = 1.02-1.86, P = 0.04) and especially in Asian populations (HR 1.49, 95% CI = 1.11-1.99, P = 0.008). But it did not have an impact on disease-free survival (HR 1.15, 95% CI = 0.76-1.74, P = 0.52). Further well-designed clinical studies with uniform assessment approaches for PD-L1 expression are warranted to verify its prognostic value. |
| Starting Page | 13920 |
| Ending Page | 13933 |
| Page Count | 14 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=23810&path%5B%5D=74912 |
| PubMed reference number | 29568405v1 |
| Alternate Webpage(s) | https://doi.org/10.18632/oncotarget.23810 |
| DOI | 10.18632/oncotarget.23810 |
| Journal | Oncotarget |
| Volume Number | 9 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Apoptosis Cell Death Confidence Intervals Distant Metastasis Hazard Ratio L1 childhood acute lymphoblastic leukemia Ligands Meta Analysis (statistical procedure) Neoplasms Overall Survival Parkinson Disease Patients Squamous Epithelial Cells Squamous cell carcinoma of esophagus cancer immunotherapy |
| Content Type | Text |
| Resource Type | Article |
